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Page 1
Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells.
Zhang KR, Jankowski CSR, Marshall R, Nair R, Más Gómez N, Alnemri A, Liu Y, Erler E, Ferrante J, Song Y, Bell BA, Baumann BH, Sterling J, Anderson B, Foshe S, Roof J, Fazelinia H, Spruce LA, Chuang JZ, Sung CH, Dhingra A, Boesze-Battaglia K, Chavali VRM, Rabinowitz JD, Mitchell CH, Dunaief JL. Zhang KR, et al. Among authors: roof j. Dis Model Mech. 2023 Jul 1;16(7):dmm050066. doi: 10.1242/dmm.050066. Epub 2023 Jul 25. Dis Model Mech. 2023. PMID: 37401371 Free PMC article.
The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses.
Moser EK, Roof J, Dybas JM, Spruce LA, Seeholzer SH, Cancro MP, Oliver PM. Moser EK, et al. Among authors: roof j. J Exp Med. 2019 Sep 2;216(9):2170-2183. doi: 10.1084/jem.20181953. Epub 2019 Jul 16. J Exp Med. 2019. PMID: 31311822 Free PMC article.
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.
Santhosh Kumar S, Naseri NN, Pather SR, Hallacli E, Ndayisaba A, Buenaventura C, Acosta K, Roof J, Fazelinia H, Spruce LA, Luk K, Khurana V, Rhoades E, Shalem O. Santhosh Kumar S, et al. Among authors: roof j. Sci Adv. 2024 Feb 9;10(6):eadj4767. doi: 10.1126/sciadv.adj4767. Epub 2024 Feb 9. Sci Adv. 2024. PMID: 38335281 Free PMC article.