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Development of an aggregation assay to screen FimH antagonists.
Abgottspon D, Rölli G, Hosch L, Steinhuber A, Jiang X, Schwardt O, Cutting B, Smiesko M, Jenal U, Ernst B, Trampuz A. Abgottspon D, et al. Among authors: jiang x. J Microbiol Methods. 2010 Sep;82(3):249-55. doi: 10.1016/j.mimet.2010.06.015. Epub 2010 Jul 8. J Microbiol Methods. 2010. PMID: 20620174
FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Lüthi C, Scharenberg M, Bezençon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B. Klein T, et al. Among authors: jiang x. J Med Chem. 2010 Dec 23;53(24):8627-41. doi: 10.1021/jm101011y. Epub 2010 Nov 24. J Med Chem. 2010. PMID: 21105658
A flow cytometry-based assay for screening FimH antagonists.
Scharenberg M, Abgottspon D, Cicek E, Jiang X, Schwardt O, Rabbani S, Ernst B. Scharenberg M, et al. Among authors: jiang x. Assay Drug Dev Technol. 2011 Oct;9(5):455-64. doi: 10.1089/adt.2010.0357. Epub 2011 Jun 15. Assay Drug Dev Technol. 2011. PMID: 21675870
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile.
Kleeb S, Pang L, Mayer K, Eris D, Sigl A, Preston RC, Zihlmann P, Sharpe T, Jakob RP, Abgottspon D, Hutter AS, Scharenberg M, Jiang X, Navarra G, Rabbani S, Smiesko M, Lüdin N, Bezençon J, Schwardt O, Maier T, Ernst B. Kleeb S, et al. Among authors: jiang x. J Med Chem. 2015 Mar 12;58(5):2221-39. doi: 10.1021/jm501524q. Epub 2015 Feb 20. J Med Chem. 2015. PMID: 25666045
FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability.
Kleeb S, Jiang X, Frei P, Sigl A, Bezençon J, Bamberger K, Schwardt O, Ernst B. Kleeb S, et al. Among authors: jiang x. J Med Chem. 2016 Apr 14;59(7):3163-82. doi: 10.1021/acs.jmedchem.5b01923. Epub 2016 Mar 18. J Med Chem. 2016. PMID: 26959338
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