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Improving the economics of NASH/NAFLD treatment through the use of systems biology.
Drug Discov Today. 2017 Oct;22(10):1532-1538. doi: 10.1016/j.drudis.2017.07.005. Epub 2017 Jul 20.
Drug Discov Today. 2017.
PMID: 28736156
Review.
Integration of Heterogeneous Biological Data in Multiscale Mechanistic Model Calibration: Application to Lung Adenocarcinoma.
Palgen JL, Perrillat-Mercerot A, Ceres N, Peyronnet E, Coudron M, Tixier E, Illigens BMW, Bosley J, L'Hostis A, Monteiro C.
Palgen JL, et al. Among authors: bosley j.
Acta Biotheor. 2022 Jul 7;70(3):19. doi: 10.1007/s10441-022-09445-3.
Acta Biotheor. 2022.
PMID: 35796890
Free PMC article.
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A quantitative systems pharmacology workflow toward optimal design and biomarker stratification of atopic dermatitis clinical trials.
Go N, Arsène S, Faddeenkov I, Galland T, Martis B S, Lefaudeux D, Wang Y, Etheve L, Jacob E, Monteiro C, Bosley J, Sansone C, Pasquali C, Lehr L, Kulesza A.
Go N, et al. Among authors: bosley j.
J Allergy Clin Immunol. 2024 May;153(5):1330-1343. doi: 10.1016/j.jaci.2023.12.031. Epub 2024 Feb 16.
J Allergy Clin Immunol. 2024.
PMID: 38369029
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Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma.
Jacob E, Perrillat-Mercerot A, Palgen JL, L'Hostis A, Ceres N, Boissel JP, Bosley J, Monteiro C, Kahoul R.
Jacob E, et al. Among authors: bosley j.
BMC Bioinformatics. 2023 Sep 4;24(1):331. doi: 10.1186/s12859-023-05430-w.
BMC Bioinformatics. 2023.
PMID: 37667175
Free PMC article.
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A quantitative systems pharmacology modeling platform for evaluating triglyceride profiles in patients with high triglycerides receiving evinacumab.
Khaksar Toroghi M, Bosley J, Powell LM, Zhang Y, Yang F, Pu X, Davis JD, Al-Huniti N.
Khaksar Toroghi M, et al. Among authors: bosley j.
CPT Pharmacometrics Syst Pharmacol. 2021 Nov;10(11):1332-1342. doi: 10.1002/psp4.12694. Epub 2021 Aug 9.
CPT Pharmacometrics Syst Pharmacol. 2021.
PMID: 34327869
Free PMC article.
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The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
Zhang C, Bjornson E, Arif M, Tebani A, Lovric A, Benfeitas R, Ozcan M, Juszczak K, Kim W, Kim JT, Bidkhori G, Ståhlman M, Bergh PO, Adiels M, Turkez H, Taskinen MR, Bosley J, Marschall HU, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
Zhang C, et al. Among authors: bosley j.
Mol Syst Biol. 2020 Apr;16(4):e9495. doi: 10.15252/msb.209495.
Mol Syst Biol. 2020.
PMID: 32337855
Free PMC article.
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When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis.
Scannell JW, Bosley J.
Scannell JW, et al. Among authors: bosley j.
PLoS One. 2016 Feb 10;11(2):e0147215. doi: 10.1371/journal.pone.0147215. eCollection 2016.
PLoS One. 2016.
PMID: 26863229
Free PMC article.
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