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P-Rex1 and P-Rex2 RacGEFs and cancer.
Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA. Srijakotre N, et al. Among authors: man j. Biochem Soc Trans. 2017 Aug 15;45(4):963-77. doi: 10.1042/BST20160269. Epub 2017 Jul 14. Biochem Soc Trans. 2017. PMID: 28710285 Review.
PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis.
Srijakotre N, Liu HJ, Nobis M, Man J, Yip HYK, Papa A, Abud HE, Anderson KI, Welch HCE, Tiganis T, Timpson P, McLean CA, Ooms LM, Mitchell CA. Srijakotre N, et al. Among authors: man j. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28056-28067. doi: 10.1073/pnas.2006445117. Epub 2020 Oct 23. Proc Natl Acad Sci U S A. 2020. PMID: 33097662 Free PMC article.
PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.
Liu HJ, Ooms LM, Srijakotre N, Man J, Vieusseux J, Waters JE, Feng Y, Bailey CG, Rasko JE, Price JT, Mitchell CA. Liu HJ, et al. Among authors: man j. J Biol Chem. 2016 Aug 12;291(33):17258-70. doi: 10.1074/jbc.M116.743401. Epub 2016 Jun 29. J Biol Chem. 2016. PMID: 27358402 Free PMC article.