PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms

Cell Metab. 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008.

Abstract

Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease* / metabolism
  • Animals
  • Brain / metabolism
  • Cell Line, Tumor
  • Mice
  • Phosphoglycerate Dehydrogenase* / genetics
  • Phosphoglycerate Dehydrogenase* / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Serine / metabolism

Substances

  • RNA, Messenger
  • Serine
  • Phosphoglycerate Dehydrogenase