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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Among authors: martinez fabregas j. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
Mapping Determinants of Cytokine Signaling via Protein Engineering.
Gorby C, Martinez-Fabregas J, Wilmes S, Moraga I. Gorby C, et al. Among authors: martinez fabregas j. Front Immunol. 2018 Sep 27;9:2143. doi: 10.3389/fimmu.2018.02143. eCollection 2018. Front Immunol. 2018. PMID: 30319612 Free PMC article. Review.
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation.
González-Arzola K, Díaz-Quintana A, Bernardo-García N, Martínez-Fábregas J, Rivero-Rodríguez F, Casado-Combreras MÁ, Elena-Real CA, Velázquez-Cruz A, Gil-Caballero S, Velázquez-Campoy A, Szulc E, Gavilán MP, Ayala I, Arranz R, Ríos RM, Salvatella X, Valpuesta JM, Hermoso JA, De la Rosa MA, Díaz-Moreno I. González-Arzola K, et al. Among authors: martinez fabregas j. Nat Struct Mol Biol. 2022 Oct;29(10):1024-1036. doi: 10.1038/s41594-022-00842-3. Epub 2022 Oct 11. Nat Struct Mol Biol. 2022. PMID: 36220893
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