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Page 1
Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy.
J Mol Cell Cardiol. 2022 Mar;164:148-155. doi: 10.1016/j.yjmcc.2021.12.003. Epub 2021 Dec 14.
J Mol Cell Cardiol. 2022.
PMID: 34919895
Free article.
Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability.
Tapio J, Kiviniemi AM, Perkiömäki J, Junttila MJ, Huikuri HV, Ukkola O, Koivunen P, Tulppo MP.
Tapio J, et al.
Am J Physiol Heart Circ Physiol. 2023 Oct 1;325(4):H629-H634. doi: 10.1152/ajpheart.00415.2023. Epub 2023 Aug 11.
Am J Physiol Heart Circ Physiol. 2023.
PMID: 37566112
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Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism.
Tapio J, Halmetoja R, Dimova EY, Mäki JM, Laitala A, Walkinshaw G, Myllyharju J, Serpi R, Koivunen P.
Tapio J, et al.
J Biol Chem. 2022 Aug;298(8):102222. doi: 10.1016/j.jbc.2022.102222. Epub 2022 Jul 1.
J Biol Chem. 2022.
PMID: 35787374
Free PMC article.
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HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD.
Laitakari A, Tapio J, Mäkelä KA, Herzig KH, Dengler F, Gylling H, Walkinshaw G, Myllyharju J, Dimova EY, Serpi R, Koivunen P.
Laitakari A, et al. Among authors: tapio j.
J Mol Med (Berl). 2020 May;98(5):719-731. doi: 10.1007/s00109-020-01903-0. Epub 2020 Apr 15.
J Mol Med (Berl). 2020.
PMID: 32296880
Free PMC article.
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Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia.
Auvinen J, Tapio J, Karhunen V, Kettunen J, Serpi R, Dimova EY, Gill D, Soininen P, Tammelin T, Mykkänen J, Puukka K, Kähönen M, Raitoharju E, Lehtimäki T, Ala-Korpela M, Raitakari OT, Keinänen-Kiukaanniemi S, Järvelin MR, Koivunen P.
Auvinen J, et al. Among authors: tapio j.
Sci Adv. 2021 Jul 14;7(29):eabi4822. doi: 10.1126/sciadv.abi4822. Print 2021 Jul.
Sci Adv. 2021.
PMID: 34261659
Free PMC article.
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Hemoglobin levels are associated with retinal vascular caliber in a middle-aged birth cohort.
Sakko S, Karpale M, Tapio J, Leppänen I, Ahokas O, Saarela V, Liinamaa MJ, Koivunen P.
Sakko S, et al. Among authors: tapio j.
Sci Rep. 2024 Apr 20;14(1):9092. doi: 10.1038/s41598-024-59688-y.
Sci Rep. 2024.
PMID: 38643302
Free PMC article.
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Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up.
Tapio J, Vähänikkilä H, Kesäniemi YA, Ukkola O, Koivunen P.
Tapio J, et al.
Sci Rep. 2021 Oct 7;11(1):19936. doi: 10.1038/s41598-021-99217-9.
Sci Rep. 2021.
PMID: 34620927
Free PMC article.
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