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2021 | 2 |
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Page 1
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
Cancer Cell. 2021 Oct 11;39(10):1404-1421.e11. doi: 10.1016/j.ccell.2021.08.009. Epub 2021 Sep 13.
Cancer Cell. 2021.
PMID: 34520734
Free article.
An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.
Oltion K, Carelli JD, Yang T, See SK, Wang HY, Kampmann M, Taunton J.
Oltion K, et al. Among authors: carelli jd.
Cell. 2023 Jan 19;186(2):346-362.e17. doi: 10.1016/j.cell.2022.12.025. Epub 2023 Jan 12.
Cell. 2023.
PMID: 36638793
Free PMC article.
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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
Freeman-Cook KD, Hoffman RL, Behenna DC, Boras B, Carelli J, Diehl W, Ferre RA, He YA, Hui A, Huang B, Huser N, Jones R, Kephart SE, Lapek J, McTigue M, Miller N, Murray BW, Nagata A, Nguyen L, Niessen S, Ninkovic S, O'Doherty I, Ornelas MA, Solowiej J, Sutton SC, Tran K, Tseng E, Visswanathan R, Xu M, Zehnder L, Zhang Q, Zhang C, Dann S.
Freeman-Cook KD, et al. Among authors: carelli j.
J Med Chem. 2021 Jul 8;64(13):9056-9077. doi: 10.1021/acs.jmedchem.1c00159. Epub 2021 Jun 10.
J Med Chem. 2021.
PMID: 34110834
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Reversible lysine-targeted probes reveal residence time-based kinase selectivity.
Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD Jr, Niessen S, Burlingame AL, Carelli JD, Taunton J.
Yang T, et al. Among authors: carelli jd.
Nat Chem Biol. 2022 Sep;18(9):934-941. doi: 10.1038/s41589-022-01019-1. Epub 2022 May 19.
Nat Chem Biol. 2022.
PMID: 35590003
Free PMC article.
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Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.
Juette MF, Carelli JD, Rundlet EJ, Brown A, Shao S, Ferguson A, Wasserman MR, Holm M, Taunton J, Blanchard SC.
Juette MF, et al. Among authors: carelli jd.
Elife. 2022 Oct 20;11:e81608. doi: 10.7554/eLife.81608.
Elife. 2022.
PMID: 36264623
Free PMC article.
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Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.
Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J.
Carelli JD, et al.
Elife. 2015 Dec 10;4:e10222. doi: 10.7554/eLife.10222.
Elife. 2015.
PMID: 26651998
Free PMC article.
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