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Page 1
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Blood. 2023 Dec 14;142(24):2079-2091. doi: 10.1182/blood.2023020331.
Blood. 2023.
PMID: 37595362
Free PMC article.
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Miller PG, Sathappa M, Moroco JA, Jiang W, Qian Y, Iqbal S, Guo Q, Giacomelli AO, Shaw S, Vernier C, Bajrami B, Yang X, Raffier C, Sperling AS, Gibson CJ, Kahn J, Jin C, Ranaghan M, Caliman A, Brousseau M, Fischer ES, Lintner R, Piccioni F, Campbell AJ, Root DE, Garvie CW, Ebert BL.
Miller PG, et al. Among authors: kahn j.
Nat Commun. 2022 Jun 30;13(1):3778. doi: 10.1038/s41467-022-30463-9.
Nat Commun. 2022.
PMID: 35773251
Free PMC article.
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PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.
Kahn JD, Miller PG, Silver AJ, Sellar RS, Bhatt S, Gibson C, McConkey M, Adams D, Mar B, Mertins P, Fereshetian S, Krug K, Zhu H, Letai A, Carr SA, Doench J, Jaiswal S, Ebert BL.
Kahn JD, et al.
Blood. 2018 Sep 13;132(11):1095-1105. doi: 10.1182/blood-2018-05-850339. Epub 2018 Jun 28.
Blood. 2018.
PMID: 29954749
Free PMC article.
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SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.
Mar BG, Chu SH, Kahn JD, Krivtsov AV, Koche R, Castellano CA, Kotlier JL, Zon RL, McConkey ME, Chabon J, Chappell R, Grauman PV, Hsieh JJ, Armstrong SA, Ebert BL.
Mar BG, et al. Among authors: kahn jd.
Blood. 2017 Dec 14;130(24):2631-2641. doi: 10.1182/blood-2017-03-775569. Epub 2017 Oct 10.
Blood. 2017.
PMID: 29018079
Free PMC article.
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Regulatory T cells and progenitor B cells are independent prognostic predictors in lower risk myelodysplastic syndromes.
Kahn JD, Chamuleau ME, Westers TM, Van de Ven PM, van Dreunen L, van Spronsen M, Ossenkoppele GJ, van de Loosdrecht AA.
Kahn JD, et al.
Haematologica. 2015 Jun;100(6):e220-2. doi: 10.3324/haematol.2014.116657. Epub 2015 Mar 6.
Haematologica. 2015.
PMID: 25749828
Free PMC article.
No abstract available.
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