Junsuke Hayashi[Author] - Search Results

Year	Number of Results
2014	1
2015	3
2016	2
2017	2
2018	2
2019	2
2021	1
2022	1
2023	1
2024	1

1

Prodrug-Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment.

Sugimoto N, Hayashi J, Funaki R, Wada SI, Wada F, Harada-Shiba M, Urata H. Sugimoto N, et al. Among authors: hayashi j. Chembiochem. 2023 Dec 14;24(24):e202300526. doi: 10.1002/cbic.202300526. Epub 2023 Oct 27. Chembiochem. 2023. PMID: 37840006

2

Influence of Aib-Containing Amphipathic Helical Chain Length in MAP(Aib)-cRGD as Carrier for siRNA Delivery.

Wada SI, Shibaike A, Hayashi J, Urata H. Wada SI, et al. Among authors: hayashi j. Chem Biodivers. 2022 Feb;19(2):e202100728. doi: 10.1002/cbdv.202100728. Epub 2021 Dec 22. Chem Biodivers. 2022. PMID: 34842340

3

Effective gene silencing activity of prodrug-type 2'-O-methyldithiomethyl siRNA compared with non-prodrug-type 2'-O-methyl siRNA.

Hayashi J, Nishigaki M, Ochi Y, Wada SI, Wada F, Nakagawa O, Obika S, Harada-Shiba M, Urata H. Hayashi J, et al. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2171-2174. doi: 10.1016/j.bmcl.2018.05.016. Epub 2018 May 8. Bioorg Med Chem Lett. 2018. PMID: 29764744

4

Aib-containing peptide analogs: cellular uptake and utilization in oligonucleotide delivery.

Wada S, Urase T, Hasegawa Y, Ban K, Sudani A, Kawai Y, Hayashi J, Urata H. Wada S, et al. Among authors: hayashi j. Bioorg Med Chem. 2014 Dec 15;22(24):6776-80. doi: 10.1016/j.bmc.2014.10.040. Bioorg Med Chem. 2014. PMID: 25468041

5

Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency.

Hayashi J, Ochi Y, Senpuku K, Wada SI, Wada F, Harada-Shiba M, Urata H. Hayashi J, et al. Bioorg Med Chem. 2024 Apr 15;104:117693. doi: 10.1016/j.bmc.2024.117693. Epub 2024 Mar 15. Bioorg Med Chem. 2024. PMID: 38552598

6

Gene silencing by 2'-O-methyldithiomethyl-modified siRNA, a prodrug-type siRNA responsive to reducing environment.

Ochi Y, Imai M, Nakagawa O, Hayashi J, Wada SI, Urata H. Ochi Y, et al. Among authors: hayashi j. Bioorg Med Chem Lett. 2016 Feb 1;26(3):845-848. doi: 10.1016/j.bmcl.2015.12.074. Epub 2015 Dec 22. Bioorg Med Chem Lett. 2016. PMID: 26755395

7

Influence of lysine residue in amphipathic helical peptides on targeted delivery of RNA into cancer cells.

Wada SI, Taniguchi K, Hamazaki H, Yamada A, Hayashi J, Uchiyama K, Urata H. Wada SI, et al. Among authors: hayashi j. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1934-1937. doi: 10.1016/j.bmcl.2019.05.044. Epub 2019 May 21. Bioorg Med Chem Lett. 2019. PMID: 31133532

8

α-Aminoisobutyric Acid-Containing Amphipathic Helical Peptide-Cyclic RGD Conjugation as a Potential Drug Delivery System for MicroRNA Replacement Therapy in Vitro.

Taniguchi K, Wada SI, Ito Y, Hayashi J, Inomata Y, Lee SW, Tanaka T, Komura K, Akao Y, Urata H, Uchiyama K. Taniguchi K, et al. Among authors: hayashi j. Mol Pharm. 2019 Nov 4;16(11):4542-4550. doi: 10.1021/acs.molpharmaceut.9b00680. Epub 2019 Oct 25. Mol Pharm. 2019. PMID: 31596588

9

Structure-activity relationship study of Aib-containing amphipathic helical peptide-cyclic RGD conjugates as carriers for siRNA delivery.

Wada SI, Takesada A, Nagamura Y, Sogabe E, Ohki R, Hayashi J, Urata H. Wada SI, et al. Among authors: hayashi j. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5378-5381. doi: 10.1016/j.bmcl.2017.11.018. Epub 2017 Nov 10. Bioorg Med Chem Lett. 2017. PMID: 29157863

10

Syntheses of prodrug-type 2'-O-methyldithiomethyl oligonucleotides modified at natural four nucleoside residues and their conversions into natural 2'-hydroxy oligonucleotides under reducing condition.

Hayashi J, Ochi Y, Morita Y, Soubou K, Ohtomo Y, Nishigaki M, Tochiyama Y, Nakagawa O, Wada SI, Urata H. Hayashi J, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5838-5844. doi: 10.1016/j.bmc.2018.10.025. Epub 2018 Oct 26. Bioorg Med Chem. 2018. PMID: 30420326

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