Jurva U - Search Results

1

Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.

Fjellström O, Akkaya S, Beisel HG, Eriksson PO, Erixon K, Gustafsson D, Jurva U, Kang D, Karis D, Knecht W, Nerme V, Nilsson I, Olsson T, Redzic A, Roth R, Sandmark J, Tigerström A, Öster L. Fjellström O, et al. Among authors: jurva u. PLoS One. 2015 Jan 28;10(1):e0113705. doi: 10.1371/journal.pone.0113705. eCollection 2015. PLoS One. 2015. PMID: 25629509 Free PMC article.

2

Identification and design of a novel series of MGAT2 inhibitors.

Barlind JG, Buckett LK, Crosby SG, Davidsson Ö, Emtenäs H, Ertan A, Jurva U, Lemurell M, Gutierrez PM, Nilsson K, O'Mahony G, Petersson AU, Redzic A, Wågberg F, Yuan ZQ. Barlind JG, et al. Among authors: jurva u. Bioorg Med Chem Lett. 2013 May 1;23(9):2721-6. doi: 10.1016/j.bmcl.2013.02.084. Epub 2013 Feb 27. Bioorg Med Chem Lett. 2013. PMID: 23541669

3

The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.

Bonn P, Brink DM, Fägerhag J, Jurva U, Robb GR, Schnecke V, Svensson Henriksson A, Waring MJ, Westerlund C. Bonn P, et al. Among authors: jurva u. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7302-5. doi: 10.1016/j.bmcl.2012.10.090. Epub 2012 Oct 27. Bioorg Med Chem Lett. 2012. PMID: 23149230

4

Mimicry of phase I drug metabolism--novel methods for metabolite characterization and synthesis.

Johansson T, Weidolf L, Jurva U. Johansson T, et al. Among authors: jurva u. Rapid Commun Mass Spectrom. 2007;21(14):2323-31. doi: 10.1002/rcm.3077. Rapid Commun Mass Spectrom. 2007. PMID: 17575570

5

Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR.

Johansson T, Jurva U, Grönberg G, Weidolf L, Masimirembwa C. Johansson T, et al. Among authors: jurva u. Drug Metab Dispos. 2009 Mar;37(3):571-9. doi: 10.1124/dmd.108.025171. Epub 2008 Dec 15. Drug Metab Dispos. 2009. PMID: 19074972

6

Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents.

Kajanus J, Antonsson T, Carlsson L, Jurva U, Pettersen A, Sundell J, Inghardt T. Kajanus J, et al. Among authors: jurva u. Bioorg Med Chem Lett. 2019 May 15;29(10):1241-1245. doi: 10.1016/j.bmcl.2019.03.006. Epub 2019 Mar 6. Bioorg Med Chem Lett. 2019. PMID: 30879840

7

Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.

Jurva U, Holmén A, Grönberg G, Masimirembwa C, Weidolf L. Jurva U, et al. Chem Res Toxicol. 2008 Apr;21(4):928-35. doi: 10.1021/tx700400c. Epub 2008 Mar 25. Chem Res Toxicol. 2008. PMID: 18361508

8

Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.

Ongarora DS, Strydom N, Wicht K, Njoroge M, Wiesner L, Egan TJ, Wittlin S, Jurva U, Masimirembwa CM, Chibale K. Ongarora DS, et al. Among authors: jurva u. Bioorg Med Chem. 2015 Sep 1;23(17):5419-32. doi: 10.1016/j.bmc.2015.07.051. Epub 2015 Jul 30. Bioorg Med Chem. 2015. PMID: 26264839

9

Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.

Inghardt T, Antonsson T, Ericsson C, Hovdal D, Johannesson P, Johansson C, Jurva U, Kajanus J, Kull B, Michaëlsson E, Pettersen A, Sjögren T, Sörensen H, Westerlund K, Lindstedt EL. Inghardt T, et al. Among authors: jurva u. J Med Chem. 2022 Sep 8;65(17):11485-11496. doi: 10.1021/acs.jmedchem.1c02141. Epub 2022 Aug 25. J Med Chem. 2022. PMID: 36005476 Free PMC article.

10

State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.

Afzelius L, Arnby CH, Broo A, Carlsson L, Isaksson C, Jurva U, Kjellander B, Kolmodin K, Nilsson K, Raubacher F, Weidolf L. Afzelius L, et al. Among authors: jurva u. Drug Metab Rev. 2007;39(1):61-86. doi: 10.1080/03602530600969374. Drug Metab Rev. 2007. PMID: 17364881

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