Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.
Bautista-Aguilera ÓM, Ismaili L, Chioua M, Andrys R, Schmidt M, Bzonek P, Martínez-Grau MÁ, Beadle CD, Vetman T, López-Muñoz F, Iriepa I, Refouvelet B, Musilek K, Marco-Contelles J.
Bautista-Aguilera ÓM, et al. Among authors: ismaili l.
Int J Mol Sci. 2020 May 30;21(11):3913. doi: 10.3390/ijms21113913.
Int J Mol Sci. 2020.
PMID: 32486316
Free PMC article.
In particular, molecule QN8 was found to be a potent and quite selective non-competitive inhibitor of hrAChE (IC(50) = 0.29 M), with K(i) value in nanomolar range (79 nM). Pertinent docking analysis confirmed this result, suggesting that this ligand is an interesting hit f …
In particular, molecule QN8 was found to be a potent and quite selective non-competitive inhibitor of hrAChE (IC(50) = 0.29 M), with K …