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Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM, Serreze DV. Ratiu JJ, et al. J Immunol. 2017 Jun 1;198(11):4255-4267. doi: 10.4049/jimmunol.1700024. Epub 2017 May 1. J Immunol. 2017. PMID: 28461573 Free PMC article.
B-lymphocytes expressing an Ig specificity recognizing the pancreatic ß-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice.
Leeth CM, Racine J, Chapman HD, Arpa B, Carrillo J, Carrascal J, Wang Q, Ratiu J, Egia-Mendikute L, Rosell-Mases E, Stratmann T, Verdaguer J, Serreze DV. Leeth CM, et al. Diabetes. 2016 Jul;65(7):1977-1987. doi: 10.2337/db15-1606. Epub 2016 Mar 9. Diabetes. 2016. PMID: 26961115 Free PMC article.