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Page 1
SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity.
Sheban D, Shani T, Maor R, Aguilera-Castrejon A, Mor N, Oldak B, Shmueli MD, Eisenberg-Lerner A, Bayerl J, Hebert J, Viukov S, Chen G, Kacen A, Krupalnik V, Chugaeva V, Tarazi S, Rodríguez-delaRosa A, Zerbib M, Ulman A, Masarwi S, Kupervaser M, Levin Y, Shema E, David Y, Novershtern N, Hanna JH, Merbl Y. Sheban D, et al. Among authors: kacen a. Mol Cell. 2022 Jan 6;82(1):106-122.e9. doi: 10.1016/j.molcel.2021.11.011. Epub 2021 Dec 6. Mol Cell. 2022. PMID: 34875212 Free article.
Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides.
Wolf-Levy H, Javitt A, Eisenberg-Lerner A, Kacen A, Ulman A, Sheban D, Dassa B, Fishbain-Yoskovitz V, Carmona-Rivera C, Kramer MP, Nudel N, Regev I, Zahavi L, Elinger D, Kaplan MJ, Morgenstern D, Levin Y, Merbl Y. Wolf-Levy H, et al. Among authors: kacen a. Nat Biotechnol. 2018 Oct 22:10.1038/nbt.4279. doi: 10.1038/nbt.4279. Online ahead of print. Nat Biotechnol. 2018. PMID: 30346940 Free PMC article.
Cyclic GMP-AMP signalling protects bacteria against viral infection.
Cohen D, Melamed S, Millman A, Shulman G, Oppenheimer-Shaanan Y, Kacen A, Doron S, Amitai G, Sorek R. Cohen D, et al. Among authors: kacen a. Nature. 2019 Oct;574(7780):691-695. doi: 10.1038/s41586-019-1605-5. Epub 2019 Sep 18. Nature. 2019. PMID: 31533127
The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.
Javitt A, Shmueli MD, Kramer MP, Kolodziejczyk AA, Cohen IJ, Radomir L, Sheban D, Kamer I, Litchfield K, Bab-Dinitz E, Zadok O, Neiens V, Ulman A, Wolf-Levy H, Eisenberg-Lerner A, Kacen A, Alon M, Rêgo AT, Stacher-Priehse E, Lindner M, Koch I, Bar J, Swanton C, Samuels Y, Levin Y, da Fonseca PCA, Elinav E, Friedman N, Meiners S, Merbl Y. Javitt A, et al. Among authors: kacen a. Nat Cancer. 2023 May;4(5):629-647. doi: 10.1038/s43018-023-00557-4. Epub 2023 May 22. Nat Cancer. 2023. PMID: 37217651
Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
Duncan-Lowey B, Tal N, Johnson AG, Rawson S, Mayer ML, Doron S, Millman A, Melamed S, Fedorenko T, Kacen A, Brandis A, Mehlman T, Amitai G, Sorek R, Kranzusch PJ. Duncan-Lowey B, et al. Among authors: kacen a. Cell. 2023 Mar 2;186(5):987-998.e15. doi: 10.1016/j.cell.2023.01.012. Epub 2023 Feb 9. Cell. 2023. PMID: 36764290 Free PMC article.
An expanded arsenal of immune systems that protect bacteria from phages.
Millman A, Melamed S, Leavitt A, Doron S, Bernheim A, Hör J, Garb J, Bechon N, Brandis A, Lopatina A, Ofir G, Hochhauser D, Stokar-Avihail A, Tal N, Sharir S, Voichek M, Erez Z, Ferrer JLM, Dar D, Kacen A, Amitai G, Sorek R. Millman A, et al. Among authors: kacen a. Cell Host Microbe. 2022 Nov 9;30(11):1556-1569.e5. doi: 10.1016/j.chom.2022.09.017. Epub 2022 Oct 26. Cell Host Microbe. 2022. PMID: 36302390 Free article.