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p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M. Kageyama S, et al. Nat Commun. 2021 Jan 4;12(1):16. doi: 10.1038/s41467-020-20185-1. Nat Commun. 2021. PMID: 33397898 Free PMC article.
p62/SQSTM1/A170: physiology and pathology.
Komatsu M, Kageyama S, Ichimura Y. Komatsu M, et al. Among authors: kageyama s. Pharmacol Res. 2012 Dec;66(6):457-62. doi: 10.1016/j.phrs.2012.07.004. Epub 2012 Jul 25. Pharmacol Res. 2012. PMID: 22841931 Review.
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M. Ichimura Y, et al. Among authors: kageyama s. Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5. Mol Cell. 2013. PMID: 24011591 Free article.
LC3B is indispensable for selective autophagy of p62 but not basal autophagy.
Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y. Maruyama Y, et al. Among authors: kageyama s. Biochem Biophys Res Commun. 2014 Mar 28;446(1):309-15. doi: 10.1016/j.bbrc.2014.02.093. Epub 2014 Feb 28. Biochem Biophys Res Commun. 2014. PMID: 24582747
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M. Kageyama S, et al. J Biol Chem. 2014 Sep 5;289(36):24944-55. doi: 10.1074/jbc.M114.580357. Epub 2014 Jul 21. J Biol Chem. 2014. PMID: 25049227 Free PMC article.
The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.
Morimoto D, Walinda E, Fukada H, Sou YS, Kageyama S, Hoshino M, Fujii T, Tsuchiya H, Saeki Y, Arita K, Ariyoshi M, Tochio H, Iwai K, Namba K, Komatsu M, Tanaka K, Shirakawa M. Morimoto D, et al. Among authors: kageyama s. Nat Commun. 2015 Jan 20;6:6116. doi: 10.1038/ncomms7116. Nat Commun. 2015. PMID: 25600778 Free PMC article.
824 results