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KDM4 Inhibition Targets Breast Cancer Stem-like Cells.
Metzger E, Stepputtis SS, Strietz J, Preca BT, Urban S, Willmann D, Allen A, Zenk F, Iovino N, Bronsert P, Proske A, Follo M, Boerries M, Stickeler E, Xu J, Wallace MB, Stafford JA, Kanouni T, Maurer J, Schüle R. Metzger E, et al. Among authors: kanouni t. Cancer Res. 2017 Nov 1;77(21):5900-5912. doi: 10.1158/0008-5472.CAN-17-1754. Epub 2017 Sep 7. Cancer Res. 2017. PMID: 28883001
Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.
Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R. Duteil D, et al. Among authors: kanouni t. Cell Rep. 2016 Oct 18;17(4):1008-1021. doi: 10.1016/j.celrep.2016.09.053. Cell Rep. 2016. PMID: 27760309 Free PMC article.
Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4.
Castex J, Willmann D, Kanouni T, Arrigoni L, Li Y, Friedrich M, Schleicher M, Wöhrle S, Pearson M, Kraut N, Méret M, Manke T, Metzger E, Schüle R, Günther T. Castex J, et al. Among authors: kanouni t. Cell Death Dis. 2017 Feb 23;8(2):e2631. doi: 10.1038/cddis.2017.48. Cell Death Dis. 2017. PMID: 28230862 Free PMC article.
Lsd1 prevents age-programed loss of beige adipocytes.
Duteil D, Tosic M, Willmann D, Georgiadi A, Kanouni T, Schüle R. Duteil D, et al. Among authors: kanouni t. Proc Natl Acad Sci U S A. 2017 May 16;114(20):5265-5270. doi: 10.1073/pnas.1702641114. Epub 2017 May 1. Proc Natl Acad Sci U S A. 2017. PMID: 28461471 Free PMC article.
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
Chen YK, Bonaldi T, Cuomo A, Del Rosario JR, Hosfield DJ, Kanouni T, Kao SC, Lai C, Lobo NA, Matuszkiewicz J, McGeehan A, O'Connell SM, Shi L, Stafford JA, Stansfield RK, Veal JM, Weiss MS, Yuen NY, Wallace MB. Chen YK, et al. Among authors: kanouni t. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874. doi: 10.1021/acsmedchemlett.7b00220. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835804 Free PMC article.
Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
Kanouni T, Severin C, Cho RW, Yuen NY, Xu J, Shi L, Lai C, Del Rosario JR, Stansfield RK, Lawton LN, Hosfield D, O'Connell S, Kreilein MM, Tavares-Greco P, Nie Z, Kaldor SW, Veal JM, Stafford JA, Chen YK. Kanouni T, et al. J Med Chem. 2020 Dec 10;63(23):14522-14529. doi: 10.1021/acs.jmedchem.0c00978. Epub 2020 Oct 9. J Med Chem. 2020. PMID: 33034194
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Wallace MB, Adams ME, Kanouni T, Mol CD, Dougan DR, Feher VA, O'Connell SM, Shi L, Halkowycz P, Dong Q. Wallace MB, et al. Among authors: kanouni t. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4156-8. doi: 10.1016/j.bmcl.2010.05.058. Epub 2010 May 20. Bioorg Med Chem Lett. 2010. PMID: 20621728
43 results