Kansy M - Search Results

1

Böhm HJ, Banner D, Bendels S, Kansy M, Kuhn B, Müller K, Obst-Sander U, Stahl M. Böhm HJ, et al. Among authors: kansy m. Chembiochem. 2004 May 3;5(5):637-43. doi: 10.1002/cbic.200301023. Chembiochem. 2004. PMID: 15122635 Review.

2

Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles.

Olsen JA, Banner DW, Seiler P, Wagner B, Tschopp T, Obst-Sander U, Kansy M, Müller K, Diederich F. Olsen JA, et al. Among authors: kansy m. Chembiochem. 2004 May 3;5(5):666-75. doi: 10.1002/cbic.200300907. Chembiochem. 2004. PMID: 15122639

3

In silico prediction of brain and CSF permeation of small molecules using PLS regression models.

Bendels S, Kansy M, Wagner B, Huwyler J. Bendels S, et al. Among authors: kansy m. Eur J Med Chem. 2008 Aug;43(8):1581-92. doi: 10.1016/j.ejmech.2007.11.011. Epub 2007 Nov 26. Eur J Med Chem. 2008. PMID: 18206268

4

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.

Huchet QA, Kuhn B, Wagner B, Kratochwil NA, Fischer H, Kansy M, Zimmerli D, Carreira EM, Müller K. Huchet QA, et al. Among authors: kansy m. J Med Chem. 2015 Nov 25;58(22):9041-60. doi: 10.1021/acs.jmedchem.5b01455. Epub 2015 Nov 17. J Med Chem. 2015. PMID: 26523333

5

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.

Olsen J, Seiler P, Wagner B, Fischer H, Tschopp T, Obst-Sander U, Banner DW, Kansy M, Müller K, Diederich F. Olsen J, et al. Among authors: kansy m. Org Biomol Chem. 2004 May 7;2(9):1339-52. doi: 10.1039/b402515f. Epub 2004 Apr 14. Org Biomol Chem. 2004. PMID: 15105924

6

Integrating molecular design resources within modern drug discovery research: the Roche experience.

Stahl M, Guba W, Kansy M. Stahl M, et al. Among authors: kansy m. Drug Discov Today. 2006 Apr;11(7-8):326-33. doi: 10.1016/j.drudis.2006.02.008. Drug Discov Today. 2006. PMID: 16580974 Review.

7

Can we discover pharmacological promiscuity early in the drug discovery process?

Peters JU, Hert J, Bissantz C, Hillebrecht A, Gerebtzoff G, Bendels S, Tillier F, Migeon J, Fischer H, Guba W, Kansy M. Peters JU, et al. Among authors: kansy m. Drug Discov Today. 2012 Apr;17(7-8):325-35. doi: 10.1016/j.drudis.2012.01.001. Epub 2012 Jan 16. Drug Discov Today. 2012. PMID: 22269136 Review.

8

A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values.

Schweizer E, Hoffmann-Röder A, Schärer K, Olsen JA, Fäh C, Seiler P, Obst-Sander U, Wagner B, Kansy M, Diederich F. Schweizer E, et al. Among authors: kansy m. ChemMedChem. 2006 Jun;1(6):611-21. doi: 10.1002/cmdc.200600015. ChemMedChem. 2006. PMID: 16892401

9

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.

Vorberg R, Trapp N, Zimmerli D, Wagner B, Fischer H, Kratochwil NA, Kansy M, Carreira EM, Müller K. Vorberg R, et al. Among authors: kansy m. ChemMedChem. 2016 Oct 6;11(19):2216-2239. doi: 10.1002/cmdc.201600325. Epub 2016 Sep 15. ChemMedChem. 2016. PMID: 27629993

10

Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors.

Schweizer E, Hoffmann-Röder A, Olsen JA, Seiler P, Obst-Sander U, Wagner B, Kansy M, Banner DW, Diederich F. Schweizer E, et al. Among authors: kansy m. Org Biomol Chem. 2006 Jun 21;4(12):2364-75. doi: 10.1039/b602585d. Epub 2006 May 10. Org Biomol Chem. 2006. PMID: 16763681

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