Kappler U - Search Results

1

De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans.

Morrow CA, Valkov E, Stamp A, Chow EW, Lee IR, Wronski A, Williams SJ, Hill JM, Djordjevic JT, Kappler U, Kobe B, Fraser JA. Morrow CA, et al. Among authors: kappler u. PLoS Pathog. 2012;8(10):e1002957. doi: 10.1371/journal.ppat.1002957. Epub 2012 Oct 11. PLoS Pathog. 2012. PMID: 23071437 Free PMC article.

2

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA. Blundell RD, et al. Among authors: kappler u. ACS Infect Dis. 2016 Sep 9;2(9):651-663. doi: 10.1021/acsinfecdis.6b00121. Epub 2016 Aug 17. ACS Infect Dis. 2016. PMID: 27759389

3

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Chitty JL, Tatzenko TL, Williams SJ, Koh YQ, Corfield EC, Butler MS, Robertson AA, Cooper MA, Kappler U, Kobe B, Fraser JA. Chitty JL, et al. Among authors: kappler u. J Biol Chem. 2017 Feb 17;292(7):3049-3059. doi: 10.1074/jbc.M116.767533. Epub 2017 Jan 6. J Biol Chem. 2017. PMID: 28062578 Free PMC article.

4

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Chitty JL, Blake KL, Blundell RD, Koh YQAE, Thompson M, Robertson AAB, Butler MS, Cooper MA, Kappler U, Williams SJ, Kobe B, Fraser JA. Chitty JL, et al. Among authors: kappler u. J Biol Chem. 2017 Jul 14;292(28):11829-11839. doi: 10.1074/jbc.M117.787994. Epub 2017 May 30. J Biol Chem. 2017. PMID: 28559277 Free PMC article.

5

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.

Kummari LK, Butler MS, Furlong E, Blundell R, Nouwens A, Silva AB, Kappler U, Fraser JA, Kobe B, Cooper MA, Robertson AAB. Kummari LK, et al. Among authors: kappler u. Bioorg Med Chem. 2018 Nov 1;26(20):5408-5419. doi: 10.1016/j.bmc.2018.09.004. Epub 2018 Sep 5. Bioorg Med Chem. 2018. PMID: 30322754

6

Molybdenum Enzymes and How They Support Virulence in Pathogenic Bacteria.

Zhong Q, Kobe B, Kappler U. Zhong Q, et al. Among authors: kappler u. Front Microbiol. 2020 Dec 11;11:615860. doi: 10.3389/fmicb.2020.615860. eCollection 2020. Front Microbiol. 2020. PMID: 33362753 Free PMC article. Review.

7

Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes.

Struwe MA, Kalimuthu P, Luo Z, Zhong Q, Ellis D, Yang J, Khadanand KC, Harmer JR, Kirk ML, McEwan AG, Clement B, Bernhardt PV, Kobe B, Kappler U. Struwe MA, et al. Among authors: kappler u. J Biol Chem. 2021 Jan-Jun;296:100672. doi: 10.1016/j.jbc.2021.100672. Epub 2021 Apr 20. J Biol Chem. 2021. PMID: 33887324 Free PMC article.

8

Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets.

Chua SMH, Wizrah MSI, Luo Z, Lim BYJ, Kappler U, Kobe B, Fraser JA. Chua SMH, et al. Among authors: kappler u. J Biol Chem. 2021 Oct;297(4):101091. doi: 10.1016/j.jbc.2021.101091. Epub 2021 Aug 17. J Biol Chem. 2021. PMID: 34416230 Free PMC article.

9

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans.

Wizrah MSI, Chua SMH, Luo Z, Manik MK, Pan M, Whyte JML, Robertson AAB, Kappler U, Kobe B, Fraser JA. Wizrah MSI, et al. Among authors: kappler u. J Biol Chem. 2022 Oct;298(10):102453. doi: 10.1016/j.jbc.2022.102453. Epub 2022 Sep 5. J Biol Chem. 2022. PMID: 36063996 Free PMC article.

10

Hfe Permease and Haemophilus influenzae Manganese Homeostasis.

Ganio K, Nasreen M, Yang Z, Maunders EA, Luo Z, Hossain SI, Ngu DHY, Ellis D, Gu J, Neville SL, Wilksch J, Gunn AP, Whittall JJ, Kobe B, Deplazes E, Kappler U, McDevitt CA. Ganio K, et al. Among authors: kappler u. ACS Infect Dis. 2024 Feb 9;10(2):436-452. doi: 10.1021/acsinfecdis.3c00407. Epub 2024 Jan 19. ACS Infect Dis. 2024. PMID: 38240689

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