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Page 1
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.
Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF. Wang H, et al. Among authors: karakose e. Nat Commun. 2017 Oct 3;8(1):767. doi: 10.1038/s41467-017-00992-9. Nat Commun. 2017. PMID: 28974674 Free PMC article.
Advances in drug discovery for human beta cell regeneration.
Karakose E, Ackeifi C, Wang P, Stewart AF. Karakose E, et al. Diabetologia. 2018 Aug;61(8):1693-1699. doi: 10.1007/s00125-018-4639-6. Epub 2018 May 16. Diabetologia. 2018. PMID: 29770834 Free PMC article. Review.
Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.
Wang P, Karakose E, Liu H, Swartz E, Ackeifi C, Zlatanic V, Wilson J, González BJ, Bender A, Takane KK, Ye L, Harb G, Pagliuca F, Homann D, Egli D, Argmann C, Scott DK, Garcia-Ocaña A, Stewart AF. Wang P, et al. Among authors: karakose e. Cell Metab. 2019 Mar 5;29(3):638-652.e5. doi: 10.1016/j.cmet.2018.12.005. Epub 2018 Dec 20. Cell Metab. 2019. PMID: 30581122 Free PMC article.
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration.
Ackeifi C, Wang P, Karakose E, Manning Fox JE, González BJ, Liu H, Wilson J, Swartz E, Berrouet C, Li Y, Kumar K, MacDonald PE, Sanchez R, Thorens B, DeVita R, Homann D, Egli D, Scott DK, Garcia-Ocaña A, Stewart AF. Ackeifi C, et al. Among authors: karakose e. Sci Transl Med. 2020 Feb 12;12(530):eaaw9996. doi: 10.1126/scitranslmed.aaw9996. Sci Transl Med. 2020. PMID: 32051230 Free PMC article.
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation.
Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN. Fu A, et al. Among authors: karakose e. Nat Metab. 2020 May;2(5):432-446. doi: 10.1038/s42255-020-0199-4. Epub 2020 May 11. Nat Metab. 2020. PMID: 32694660 Free PMC article.
Aberrant methylation underlies insulin gene expression in human insulinoma.
Karakose E, Wang H, Inabnet W, Thakker RV, Libutti S, Fernandez-Ranvier G, Suh H, Stevenson M, Kinoshita Y, Donovan M, Antipin Y, Li Y, Liu X, Jin F, Wang P, Uzilov A, Argmann C, Schadt EE, Stewart AF, Scott DK, Lambertini L. Karakose E, et al. Nat Commun. 2020 Oct 15;11(1):5210. doi: 10.1038/s41467-020-18839-1. Nat Commun. 2020. PMID: 33060578 Free PMC article.
Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells.
Wang P, Karakose E, Argmann C, Wang H, Balev M, Brody RI, Rivas HG, Liu X, Wood O, Liu H, Choleva L, Hasson D, Bernstein E, Paulo JA, Scott DK, Lambertini L, DeCaprio JA, Stewart AF. Wang P, et al. Among authors: karakose e. J Clin Invest. 2022 Aug 1;132(15):e157086. doi: 10.1172/JCI157086. J Clin Invest. 2022. PMID: 35700053 Free PMC article.
Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.
Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB, Gómez-Banoy N, Karakose E, Tanase M, Doridot L, Alvarsson A, Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart AF, Lo JC, Herman MA, Garcia-Ocaña A, Scott DK. Katz LS, et al. Among authors: karakose e. Nat Commun. 2022 Jul 30;13(1):4423. doi: 10.1038/s41467-022-32162-x. Nat Commun. 2022. PMID: 35908073 Free PMC article.
26 results