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Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Chrustowicz J, Sherpa D, Li J, Langlois CR, Papadopoulou EC, Vu DT, Hehl LA, Karayel Ö, Beier V, von Gronau S, Müller J, Prabu JR, Mann M, Kleiger G, Alpi AF, Schulman BA. Chrustowicz J, et al. Among authors: karayel o. Mol Cell. 2024 Jan 18;84(2):293-308.e14. doi: 10.1016/j.molcel.2023.11.027. Epub 2023 Dec 18. Mol Cell. 2024. PMID: 38113892 Free article.
A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.
Schmidt S, Stautner C, Vu DT, Heinz A, Regensburger M, Karayel O, Trümbach D, Artati A, Kaltenhäuser S, Nassef MZ, Hembach S, Steinert L, Winner B, Jürgen W, Jastroch M, Luecken MD, Theis FJ, Westmeyer GG, Adamski J, Mann M, Hiller K, Giesert F, Vogt Weisenhorn DM, Wurst W. Schmidt S, et al. Among authors: karayel o. Nat Commun. 2023 Nov 23;14(1):7674. doi: 10.1038/s41467-023-42862-7. Nat Commun. 2023. PMID: 37996418 Free PMC article.
Mitochondrial phosphoproteomes are functionally specialized across tissues.
Hansen FM, Kremer LS, Karayel O, Bludau I, Larsson NG, Kühl I, Mann M. Hansen FM, et al. Among authors: karayel o. Life Sci Alliance. 2023 Nov 20;7(2):e202302147. doi: 10.26508/lsa.202302147. Print 2024 Feb. Life Sci Alliance. 2023. PMID: 37984987 Free PMC article.
Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq.
Geiger-Schuller K, Eraslan B, Kuksenko O, Dey KK, Jagadeesh KA, Thakore PI, Karayel O, Yung AR, Rajagopalan A, Meireles AM, Yang KD, Amir-Zilberstein L, Delorey T, Phillips D, Raychowdhury R, Moussion C, Price AL, Hacohen N, Doench JG, Uhler C, Rozenblatt-Rosen O, Regev A. Geiger-Schuller K, et al. Among authors: karayel o. bioRxiv [Preprint]. 2023 Jan 24:2023.01.23.525198. doi: 10.1101/2023.01.23.525198. bioRxiv. 2023. PMID: 36747789 Free PMC article. Preprint.
Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation.
Sherpa D, Mueller J, Karayel Ö, Xu P, Yao Y, Chrustowicz J, Gottemukkala KV, Baumann C, Gross A, Czarnecki O, Zhang W, Gu J, Nilvebrant J, Sidhu SS, Murray PJ, Mann M, Weiss MJ, Schulman BA, Alpi AF. Sherpa D, et al. Among authors: karayel o. Elife. 2022 Dec 2;11:e77937. doi: 10.7554/eLife.77937. Elife. 2022. PMID: 36459484 Free PMC article.
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells.
Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman SR, Seruggia D, Zhang K, Fujiwara Y, Donovan KA, Zhu Q, Yang H, Nabet B, Gray NS, Mann M, Fischer ES, Adelman K, Orkin SH. Mehta S, et al. Among authors: karayel o. Cell Chem Biol. 2022 Aug 18;29(8):1273-1287.e8. doi: 10.1016/j.chembiol.2022.06.007. Epub 2022 Jul 14. Cell Chem Biol. 2022. PMID: 35839780 Free PMC article.
34 results