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Page 1
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
Axelrod CL, Fealy CE, Erickson ML, Davuluri G, Fujioka H, Dantas WS, Huang E, Pergola K, Mey JT, King WT, Mulya A, Hsia D, Burguera B, Tandler B, Hoppel CL, Kirwan JP. Axelrod CL, et al. Among authors: pergola k. Metabolism. 2021 Aug;121:154803. doi: 10.1016/j.metabol.2021.154803. Epub 2021 Jun 4. Metabolism. 2021. PMID: 34090870 Free PMC article. Clinical Trial.
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.
Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE. Wall JM, et al. Among authors: pergola k. Dis Model Mech. 2021 Jul 1;14(7):dmm048603. doi: 10.1242/dmm.048603. Epub 2021 Jul 12. Dis Model Mech. 2021. PMID: 34160014 Free PMC article.
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP. Axelrod CL, et al. Among authors: pergola k. EMBO Mol Med. 2020 Jul 7;12(7):e12088. doi: 10.15252/emmm.202012088. Epub 2020 Jun 10. EMBO Mol Med. 2020. PMID: 32519812 Free PMC article.
Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15.
Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP. Zunica ERM, et al. Among authors: pergola k. Cancer Metab. 2021 Oct 9;9(1):36. doi: 10.1186/s40170-021-00274-5. Cancer Metab. 2021. PMID: 34627389 Free PMC article.
Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics.
King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP. King WT, et al. Among authors: pergola k. J Biol Chem. 2021 Oct;297(4):101196. doi: 10.1016/j.jbc.2021.101196. Epub 2021 Sep 13. J Biol Chem. 2021. PMID: 34529976 Free PMC article.