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Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex.
Uzquiano A, Kedaigle AJ, Pigoni M, Paulsen B, Adiconis X, Kim K, Faits T, Nagaraja S, Antón-Bolaños N, Gerhardinger C, Tucewicz A, Murray E, Jin X, Buenrostro J, Chen F, Velasco S, Regev A, Levin JZ, Arlotta P. Uzquiano A, et al. Among authors: kedaigle aj. Cell. 2022 Sep 29;185(20):3770-3788.e27. doi: 10.1016/j.cell.2022.09.010. Cell. 2022. PMID: 36179669 Free PMC article.
Systematic comparison of single-cell and single-nucleus RNA-sequencing methods.
Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT, Kwon JYH, Barak B, Ge W, Kedaigle AJ, Carroll S, Li S, Hacohen N, Rozenblatt-Rosen O, Shalek AK, Villani AC, Regev A, Levin JZ. Ding J, et al. Among authors: kedaigle aj. Nat Biotechnol. 2020 Jun;38(6):737-746. doi: 10.1038/s41587-020-0465-8. Epub 2020 Apr 6. Nat Biotechnol. 2020. PMID: 32341560 Free PMC article.
Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods.
Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT, Kwon JYH, Barak B, Ge W, Kedaigle AJ, Carroll S, Li S, Hacohen N, Rozenblatt-Rosen O, Shalek AK, Villani AC, Regev A, Levin JZ. Ding J, et al. Among authors: kedaigle aj. Nat Biotechnol. 2020 Jun;38(6):756. doi: 10.1038/s41587-020-0534-z. Nat Biotechnol. 2020. PMID: 32341567
Autism genes converge on asynchronous development of shared neuron classes.
Paulsen B, Velasco S, Kedaigle AJ, Pigoni M, Quadrato G, Deo AJ, Adiconis X, Uzquiano A, Sartore R, Yang SM, Simmons SK, Symvoulidis P, Kim K, Tsafou K, Podury A, Abbate C, Tucewicz A, Smith SN, Albanese A, Barrett L, Sanjana NE, Shi X, Chung K, Lage K, Boyden ES, Regev A, Levin JZ, Arlotta P. Paulsen B, et al. Among authors: kedaigle aj. Nature. 2022 Feb;602(7896):268-273. doi: 10.1038/s41586-021-04358-6. Epub 2022 Feb 2. Nature. 2022. PMID: 35110736 Free PMC article.
Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity.
Pigoni M, Uzquiano A, Paulsen B, Kedaigle AJ, Yang SM, Symvoulidis P, Adiconis X, Velasco S, Sartore R, Kim K, Tucewicz A, Tropp SY, Tsafou K, Jin X, Barrett L, Chen F, Boyden ES, Regev A, Levin JZ, Arlotta P. Pigoni M, et al. Among authors: kedaigle aj. Hum Mol Genet. 2023 Sep 5;32(18):2773-2786. doi: 10.1093/hmg/ddad107. Hum Mol Genet. 2023. PMID: 37384417
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA. Bielecki P, et al. Among authors: kedaigle aj. Nature. 2021 Apr;592(7852):128-132. doi: 10.1038/s41586-021-03188-w. Epub 2021 Feb 3. Nature. 2021. PMID: 33536623 Free PMC article.
Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.
Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. Lim RG, et al. Among authors: kedaigle aj. Cell Rep. 2017 May 16;19(7):1365-1377. doi: 10.1016/j.celrep.2017.04.021. Cell Rep. 2017. PMID: 28514657 Free PMC article.
Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.
Akimov SS, Jiang M, Kedaigle AJ, Arbez N, Marque LO, Eddings CR, Ranum PT, Whelan E, Tang A, Wang R, DeVine LR, Talbot CC, Cole RN, Ratovitski T, Davidson BL, Fraenkel E, Ross CA. Akimov SS, et al. Among authors: kedaigle aj. Hum Mol Genet. 2021 Nov 30;30(24):2469-2487. doi: 10.1093/hmg/ddab200. Hum Mol Genet. 2021. PMID: 34296279 Free PMC article.
17 results