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Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.
Smyth LCD, Murray HC, Hill M, van Leeuwen E, Highet B, Magon NJ, Osanlouy M, Mathiesen SN, Mockett B, Singh-Bains MK, Morris VK, Clarkson AN, Curtis MA, Abraham WC, Hughes SM, Faull RLM, Kettle AJ, Dragunow M, Hampton MB. Smyth LCD, et al. Among authors: kettle aj. Acta Neuropathol Commun. 2022 Mar 24;10(1):38. doi: 10.1186/s40478-022-01347-2. Acta Neuropathol Commun. 2022. PMID: 35331340 Free PMC article.
Reactions of superoxide with myeloperoxidase.
Kettle AJ, Anderson RF, Hampton MB, Winterbourn CC. Kettle AJ, et al. Biochemistry. 2007 Apr 24;46(16):4888-97. doi: 10.1021/bi602587k. Epub 2007 Mar 24. Biochemistry. 2007. PMID: 17381162
2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation.
Tidén AK, Sjögren T, Svensson M, Bernlind A, Senthilmohan R, Auchère F, Norman H, Markgren PO, Gustavsson S, Schmidt S, Lundquist S, Forbes LV, Magon NJ, Paton LN, Jameson GN, Eriksson H, Kettle AJ. Tidén AK, et al. Among authors: kettle aj. J Biol Chem. 2011 Oct 28;286(43):37578-89. doi: 10.1074/jbc.M111.266981. Epub 2011 Aug 31. J Biol Chem. 2011. PMID: 21880720 Free PMC article.
152 results