Addressing the genetic/nongenetic duality in cancer with systems biology

Trends Cancer. 2023 Mar;9(3):185-187. doi: 10.1016/j.trecan.2022.12.004. Epub 2023 Jan 11.

Abstract

The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Neoplasms* / genetics
  • Systems Biology*