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Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.
Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E. Cloutier N, et al. Among authors: khan wi. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31. Proc Natl Acad Sci U S A. 2018. PMID: 29386381 Free PMC article.
Serotonin has a key role in pathogenesis of experimental colitis.
Ghia JE, Li N, Wang H, Collins M, Deng Y, El-Sharkawy RT, Côté F, Mallet J, Khan WI. Ghia JE, et al. Among authors: khan wi. Gastroenterology. 2009 Nov;137(5):1649-60. doi: 10.1053/j.gastro.2009.08.041. Epub 2009 Aug 23. Gastroenterology. 2009. PMID: 19706294
Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease.
Haq S, Wang H, Grondin J, Banskota S, Marshall JK, Khan II, Chauhan U, Cote F, Kwon YH, Philpott D, Brumell JH, Surette M, Steinberg GR, Khan WI. Haq S, et al. Among authors: khan wi, khan ii. Sci Adv. 2021 Nov 5;7(45):eabi6442. doi: 10.1126/sciadv.abi6442. Epub 2021 Nov 5. Sci Adv. 2021. PMID: 34739317 Free PMC article.
Serotonin in the gut: Blessing or a curse.
Banskota S, Ghia JE, Khan WI. Banskota S, et al. Among authors: khan wi. Biochimie. 2019 Jun;161:56-64. doi: 10.1016/j.biochi.2018.06.008. Epub 2018 Jun 14. Biochimie. 2019. PMID: 29909048 Review.
100 results