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A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner.
Dagia NM, Agarwal G, Kamath DV, Chetrapal-Kunwar A, Gupte RD, Jadhav MG, Dadarkar SS, Trivedi J, Kulkarni-Almeida AA, Kharas F, Fonseca LC, Kumar S, Bhonde MR. Dagia NM, et al. Among authors: kharas f. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. doi: 10.1152/ajpcell.00461.2009. Epub 2010 Jan 20. Am J Physiol Cell Physiol. 2010. PMID: 20089935 Free article.
Novel diarylheptanoids as inhibitors of TNF-α production.
Dhuru S, Bhedi D, Gophane D, Hirbhagat K, Nadar V, More D, Parikh S, Dalal R, Fonseca LC, Kharas F, Vadnal PY, Vishwakarma RA, Sivaramakrishnan H. Dhuru S, et al. Among authors: kharas f. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3784-7. doi: 10.1016/j.bmcl.2011.04.040. Epub 2011 Apr 22. Bioorg Med Chem Lett. 2011. PMID: 21600765