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High bone mass in mice expressing a mutant LRP5 gene.
Babij P, Zhao W, Small C, Kharode Y, Yaworsky PJ, Bouxsein ML, Reddy PS, Bodine PV, Robinson JA, Bhat B, Marzolf J, Moran RA, Bex F. Babij P, et al. J Bone Miner Res. 2003 Jun;18(6):960-74. doi: 10.1359/jbmr.2003.18.6.960. J Bone Miner Res. 2003. PMID: 12817748 Free article.
(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.
Pelletier JC, Lundquist JT 4th, Gilbert AM, Alon N, Bex FJ, Bhat BM, Bursavich MG, Coleburn VE, Felix LA, Green DM, Green P, Hauze DB, Kharode YP, Lam HS, Lockhead SR, Magolda RL, Matteo JJ, Mehlmann JF, Milligan C, Murrills RJ, Pirrello J, Selim S, Sharp MC, Unwalla RJ, Vera MD, Wrobel JE, Yaworsky P, Bodine PV. Pelletier JC, et al. Among authors: kharode yp. J Med Chem. 2009 Nov 26;52(22):6962-5. doi: 10.1021/jm9014197. J Med Chem. 2009. PMID: 19856966
Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse.
Murrills RJ, Fukayama S, Boschelli F, Matteo JJ, Owens J, Golas JM, Patel D, Lane G, Liu YB, Carter L, Jussif J, Spaulding V, Wang YD, Boschelli DH, McKew JC, Li XJ, Lockhead S, Milligan C, Kharode YP, Diesl V, Bai Y, Follettie M, Bex FJ, Komm B, Bodine PV. Murrills RJ, et al. Among authors: kharode yp. J Pharmacol Exp Ther. 2012 Mar;340(3):676-87. doi: 10.1124/jpet.111.185793. Epub 2011 Dec 9. J Pharmacol Exp Ther. 2012. PMID: 22171089
Hit to lead studies on (hetero)arylpyrimidines--agonists of the canonical Wnt-beta-catenin cellular messaging system.
Gilbert AM, Bursavich MG, Alon N, Bhat BM, Bex FJ, Cain M, Coleburn V, Gironda V, Green P, Hauze DB, Kharode Y, Krishnamurthy G, Kirisits M, Lam HS, Liu YB, Lombardi S, Matteo J, Murrills R, Robinson JA, Selim S, Sharp M, Unwalla R, Varadarajan U, Zhao W, Yaworsky PJ. Gilbert AM, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):366-70. doi: 10.1016/j.bmcl.2009.10.093. Epub 2009 Oct 25. Bioorg Med Chem Lett. 2010. PMID: 19897365
22 results