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An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):16938-16948. doi: 10.1073/pnas.2000312117. Epub 2020 Jul 2.
Proc Natl Acad Sci U S A. 2020.
PMID: 32616570
Free PMC article.
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter.
Zhu Y, Zou X, Dean AE, Brien JO, Gao Y, Tran EL, Park SH, Liu G, Kieffer MB, Jiang H, Stauffer ME, Hart R, Quan S, Satchell KJF, Horikoshi N, Bonini M, Gius D.
Zhu Y, et al. Among authors: kieffer mb.
Nat Commun. 2019 Jun 3;10(1):2399. doi: 10.1038/s41467-019-10352-4.
Nat Commun. 2019.
PMID: 31160585
Free PMC article.
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The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling.
Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, Stephen AG, Holderfield M, Satchell KJF.
Biancucci M, et al. Among authors: kieffer mb.
Sci Signal. 2018 Oct 2;11(550):eaat8335. doi: 10.1126/scisignal.aat8335.
Sci Signal. 2018.
PMID: 30279169
Free PMC article.
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