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Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis.
Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H. Kikuchi S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):962-4. doi: 10.1107/S1744309112032435. Epub 2012 Jul 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22869133 Free PMC article.
A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions.
Khalaj M, Abbasi A, Yamanishi H, Akiyama K, Wakitani S, Kikuchi S, Hirose M, Yuzuriha M, Magari M, Degheidy HA, Abe K, Ogura A, Hashimoto H, Kunieda T. Khalaj M, et al. Among authors: kikuchi s. J Biol Chem. 2014 Feb 7;289(6):3811-24. doi: 10.1074/jbc.M113.514752. Epub 2013 Dec 19. J Biol Chem. 2014. PMID: 24356953 Free PMC article.
Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno SI, Tanaka K, Hashimoto H. Hara K, et al. Among authors: kikuchi s. J Biol Chem. 2017 Oct 27;292(43):17658-17667. doi: 10.1074/jbc.M117.804237. Epub 2017 Sep 8. J Biol Chem. 2017. PMID: 28887307 Free PMC article.
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N. Inoue A, et al. Among authors: kikuchi s. J Biol Chem. 2014 Mar 7;289(10):7109-7120. doi: 10.1074/jbc.M113.520429. Epub 2014 Jan 28. J Biol Chem. 2014. PMID: 24474685 Free PMC article.
C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers.
Nanaura H, Kawamukai H, Fujiwara A, Uehara T, Aiba Y, Nakanishi M, Shiota T, Hibino M, Wiriyasermkul P, Kikuchi S, Nagata R, Matsubayashi M, Shinkai Y, Niwa T, Mannen T, Morikawa N, Iguchi N, Kiriyama T, Morishima K, Inoue R, Sugiyama M, Oda T, Kodera N, Toma-Fukai S, Sato M, Taguchi H, Nagamori S, Shoji O, Ishimori K, Matsumura H, Sugie K, Saio T, Yoshizawa T, Mori E. Nanaura H, et al. Among authors: kikuchi s. Nat Commun. 2021 Sep 6;12(1):5301. doi: 10.1038/s41467-021-25560-0. Nat Commun. 2021. PMID: 34489423 Free PMC article.
Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways.
Ito SS, Nakagawa Y, Matsubayashi M, Sakaguchi YM, Kobashigawa S, Matsui TK, Nanaura H, Nakanishi M, Kitayoshi F, Kikuchi S, Kajihara A, Tamaki S, Sugie K, Kashino G, Takahashi A, Hasegawa M, Mori E, Kirita T. Ito SS, et al. Among authors: kikuchi s. J Biol Chem. 2020 Sep 11;295(37):12946-12961. doi: 10.1074/jbc.RA120.013726. Epub 2020 Jul 16. J Biol Chem. 2020. PMID: 32675286 Free PMC article.
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, Rodiles S, Negron SM, Bernard SM, Tran E, Pollock J, Tabatabaei A, Contreras V, Williams HN, Pastuszka MK, Sigler JJ, Pettazzoni P, Rudolph MG, Classen M, Brugger D, Claiborne C, Plancher JM, Cuartas I, Seoane J, Burgess LE, Abraham RT, Weinstein DS, Simon GM, Patricelli MP, Kinsella TM. Baltgalvis KA, et al. Among authors: kikuchi s. Nature. 2024 Apr 24. doi: 10.1038/s41586-024-07318-y. Online ahead of print. Nature. 2024. PMID: 38658751
2,490 results