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GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle.
Marcotte GR, Miller MJ, Kunz HE, Ryan ZC, Strub MD, Vanderboom PM, Heppelmann CJ, Chau S, Von Ruff ZD, Kilroe SP, McKeen AT, Dierdorff JM, Stern JI, Nath KA, Grueter CE, Lira VA, Judge AR, Rasmussen BB, Nair KS, Lanza IR, Ebert SM, Adams CM. Marcotte GR, et al. Among authors: kilroe sp. JCI Insight. 2023 Nov 22;8(22):e171772. doi: 10.1172/jci.insight.171772. JCI Insight. 2023. PMID: 37815864 Free PMC article.
Muscle damaging eccentric exercise attenuates disuse-induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men.
Jameson TSO, Kilroe SP, Fulford J, Abdelrahman DR, Murton AJ, Dirks ML, Stephens FB, Wall BT. Jameson TSO, et al. Among authors: kilroe sp. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E674-E688. doi: 10.1152/ajpendo.00294.2021. Epub 2021 Oct 11. Am J Physiol Endocrinol Metab. 2021. PMID: 34632796 Free PMC article.