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PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.
Kim MK, Chae YN, Son MH, Kim SH, Kim JK, Moon HS, Park CS, Bae MH, Kim E, Han T, Choi HH, Shin YA, Ahn BN, Lee CH, Lim JI, Shin CY. Kim MK, et al. Among authors: kim e, kim jk, kim sh. Eur J Pharmacol. 2008 Oct 24;595(1-3):119-25. doi: 10.1016/j.ejphar.2008.07.066. Epub 2008 Aug 12. Eur J Pharmacol. 2008. PMID: 18727927
Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ. Suh YG, et al. Among authors: kim nj, kim mk. J Med Chem. 2008 Oct 23;51(20):6318-33. doi: 10.1021/jm8003416. Epub 2008 Oct 1. J Med Chem. 2008. PMID: 18826205
PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.
Kim MK, Chae YN, Kim HS, Choi SH, Son MH, Kim SH, Kim JK, Moon HS, Park SK, Shin YA, Kim JG, Lee CH, Lim JI, Shin CY. Kim MK, et al. Among authors: kim jk, kim sh, kim hs, kim jg. Arch Pharm Res. 2009 May;32(5):721-7. doi: 10.1007/s12272-009-1511-8. Epub 2009 May 27. Arch Pharm Res. 2009. PMID: 19471887
Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.
Kim HJ, Kwak WY, Min JP, Lee JY, Yoon TH, Kim HD, Shin CY, Kim MK, Choi SH, Kim HS, Yang EK, Cheong YH, Chae YN, Park KJ, Jang JM, Choi SJ, Son MH, Kim SH, Yoo M, Lee BJ. Kim HJ, et al. Among authors: kim sh, kim hs, kim hd, kim mk. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3809-12. doi: 10.1016/j.bmcl.2011.04.029. Epub 2011 Apr 13. Bioorg Med Chem Lett. 2011. PMID: 21570283
4,393 results