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Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.
Chauhan S, Ahmed Z, Bradfute SB, Arko-Mensah J, Mandell MA, Won Choi S, Kimura T, Blanchet F, Waller A, Mudd MH, Jiang S, Sklar L, Timmins GS, Maphis N, Bhaskar K, Piguet V, Deretic V. Chauhan S, et al. Among authors: kimura t. Nat Commun. 2015 Oct 27;6:8620. doi: 10.1038/ncomms9620. Nat Commun. 2015. PMID: 26503418 Free PMC article.
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Münch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V. Mandell MA, et al. Among authors: kimura t. Dev Cell. 2014 Aug 25;30(4):394-409. doi: 10.1016/j.devcel.2014.06.013. Epub 2014 Aug 7. Dev Cell. 2014. PMID: 25127057 Free PMC article.
Secretory autophagy.
Ponpuak M, Mandell MA, Kimura T, Chauhan S, Cleyrat C, Deretic V. Ponpuak M, et al. Among authors: kimura t. Curr Opin Cell Biol. 2015 Aug;35:106-16. doi: 10.1016/j.ceb.2015.04.016. Epub 2015 May 17. Curr Opin Cell Biol. 2015. PMID: 25988755 Free PMC article. Review.
Cellular and molecular mechanism for secretory autophagy.
Kimura T, Jia J, Claude-Taupin A, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V. Kimura T, et al. Autophagy. 2017 Jun 3;13(6):1084-1085. doi: 10.1080/15548627.2017.1307486. Epub 2017 Apr 3. Autophagy. 2017. PMID: 28368721 Free PMC article.
Immunologic manifestations of autophagy.
Deretic V, Kimura T, Timmins G, Moseley P, Chauhan S, Mandell M. Deretic V, et al. Among authors: kimura t. J Clin Invest. 2015 Jan;125(1):75-84. doi: 10.1172/JCI73945. Epub 2015 Jan 2. J Clin Invest. 2015. PMID: 25654553 Free PMC article. Review.
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