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The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease.
Patton JT, Lustberg ME, Lozanski G, Garman SL, Towns WH, Drohan CM, Lehman A, Zhang X, Bolon B, Pan L, Kinghorn AD, Grever MR, Lucas DM, Baiocchi RA. Patton JT, et al. Among authors: kinghorn ad. Oncotarget. 2015 Feb 20;6(5):2693-708. doi: 10.18632/oncotarget.2098. Oncotarget. 2015. PMID: 25393910 Free PMC article.
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.
Lucas DM, Edwards RB, Lozanski G, West DA, Shin JD, Vargo MA, Davis ME, Rozewski DM, Johnson AJ, Su BN, Goettl VM, Heerema NA, Lin TS, Lehman A, Zhang X, Jarjoura D, Newman DJ, Byrd JC, Kinghorn AD, Grever MR. Lucas DM, et al. Among authors: kinghorn ad. Blood. 2009 May 7;113(19):4656-66. doi: 10.1182/blood-2008-09-175430. Epub 2009 Feb 3. Blood. 2009. PMID: 19190247 Free PMC article.
Bioactivity-guided isolation of cytotoxic sesquiterpenes of Rolandra fruticosa.
Pan L, Lantvit DD, Riswan S, Kardono LB, Chai HB, de Blanco EJ, Farnsworth NR, Soejarto DD, Swanson SM, Kinghorn AD. Pan L, et al. Among authors: kinghorn ad. Phytochemistry. 2010 Apr;71(5-6):635-40. doi: 10.1016/j.phytochem.2010.01.012. Epub 2010 Feb 25. Phytochemistry. 2010. PMID: 20189206 Free PMC article.
Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells.
Gupta SV, Sass EJ, Davis ME, Edwards RB, Lozanski G, Heerema NA, Lehman A, Zhang X, Jarjoura D, Byrd JC, Pan L, Chan KK, Kinghorn AD, Phelps MA, Grever MR, Lucas DM. Gupta SV, et al. Among authors: kinghorn ad. AAPS J. 2011 Sep;13(3):357-64. doi: 10.1208/s12248-011-9276-7. Epub 2011 May 4. AAPS J. 2011. PMID: 21538216 Free PMC article.
418 results