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Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Van Quaquebeke E, Simon G, André A, Dewelle J, El Yazidi M, Bruyneel F, Tuti J, Nacoulma O, Guissou P, Decaestecker C, Braekman JC, Kiss R, Darro F. Van Quaquebeke E, et al. Among authors: kiss r. J Med Chem. 2005 Feb 10;48(3):849-56. doi: 10.1021/jm049405a. J Med Chem. 2005. PMID: 15689169
Anti-galectin compounds as potential anti-cancer drugs.
Ingrassia L, Camby I, Lefranc F, Mathieu V, Nshimyumukiza P, Darro F, Kiss R. Ingrassia L, et al. Among authors: kiss r. Curr Med Chem. 2006;13(29):3513-27. doi: 10.2174/092986706779026219. Curr Med Chem. 2006. PMID: 17168720 Review.
2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.
Van Quaquebeke E, Mahieu T, Dumont P, Dewelle J, Ribaucour F, Simon G, Sauvage S, Gaussin JF, Tuti J, El Yazidi M, Van Vynckt F, Mijatovic T, Lefranc F, Darro F, Kiss R. Van Quaquebeke E, et al. Among authors: kiss r. J Med Chem. 2007 Aug 23;50(17):4122-34. doi: 10.1021/jm070315q. Epub 2007 Jul 21. J Med Chem. 2007. PMID: 17658777
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Lamoral-Theys D, Andolfi A, Van Goietsenoven G, Cimmino A, Le Calvé B, Wauthoz N, Mégalizzi V, Gras T, Bruyère C, Dubois J, Mathieu V, Kornienko A, Kiss R, Evidente A. Lamoral-Theys D, et al. Among authors: kiss r. J Med Chem. 2009 Oct 22;52(20):6244-56. doi: 10.1021/jm901031h. J Med Chem. 2009. PMID: 19788245 Free PMC article.
Lycorine and its derivatives for anticancer drug design.
Lamoral-Theys D, Decaestecker C, Mathieu V, Dubois J, Kornienko A, Kiss R, Evidente A, Pottier L. Lamoral-Theys D, et al. Among authors: kiss r. Mini Rev Med Chem. 2010 Jan;10(1):41-50. doi: 10.2174/138955710791112604. Mini Rev Med Chem. 2010. PMID: 20105122 Review.
999 results