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A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection.
Langhauser F, Casas AI, Dao VT, Guney E, Menche J, Geuss E, Kleikers PWM, López MG, Barabási AL, Kleinschnitz C, Schmidt HHHW. Langhauser F, et al. Among authors: kleikers pwm. NPJ Syst Biol Appl. 2018 Feb 5;4:8. doi: 10.1038/s41540-017-0039-7. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29423274 Free PMC article.
NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.
Casas AI, Geuss E, Kleikers PWM, Mencl S, Herrmann AM, Buendia I, Egea J, Meuth SG, Lopez MG, Kleinschnitz C, Schmidt HHHW. Casas AI, et al. Among authors: kleikers pwm. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12315-12320. doi: 10.1073/pnas.1705034114. Epub 2017 Oct 31. Proc Natl Acad Sci U S A. 2017. PMID: 29087944 Free PMC article.
From single drug targets to synergistic network pharmacology in ischemic stroke.
Casas AI, Hassan AA, Larsen SJ, Gomez-Rangel V, Elbatreek M, Kleikers PWM, Guney E, Egea J, López MG, Baumbach J, Schmidt HHHW. Casas AI, et al. Among authors: kleikers pwm. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7129-7136. doi: 10.1073/pnas.1820799116. Epub 2019 Mar 20. Proc Natl Acad Sci U S A. 2019. PMID: 30894481 Free PMC article.
Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.
Radermacher KA, Wingler K, Langhauser F, Altenhöfer S, Kleikers P, Hermans JJ, Hrabě de Angelis M, Kleinschnitz C, Schmidt HH. Radermacher KA, et al. Antioxid Redox Signal. 2013 Apr 20;18(12):1418-27. doi: 10.1089/ars.2012.4797. Epub 2012 Oct 16. Antioxid Redox Signal. 2013. PMID: 22937798 Free PMC article. Review.
The 1027th target candidate in stroke: Will NADPH oxidase hold up?
Radermacher KA, Wingler K, Kleikers P, Altenhöfer S, Jr Hermans J, Kleinschnitz C, Hhw Schmidt H. Radermacher KA, et al. Exp Transl Stroke Med. 2012 May 24;4(1):11. doi: 10.1186/2040-7378-4-11. Exp Transl Stroke Med. 2012. PMID: 22625431 Free PMC article.
19 results