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Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W. Lu Y, et al. Among authors: klenk hd. Antiviral Res. 2015 Aug;120:89-100. doi: 10.1016/j.antiviral.2015.05.006. Epub 2015 May 26. Antiviral Res. 2015. PMID: 26022200
The hemagglutinin: a determinant of pathogenicity.
Böttcher-Friebertshäuser E, Garten W, Matrosovich M, Klenk HD. Böttcher-Friebertshäuser E, et al. Among authors: klenk hd. Curr Top Microbiol Immunol. 2014;385:3-34. doi: 10.1007/82_2014_384. Curr Top Microbiol Immunol. 2014. PMID: 25031010 Review.
New low-viscosity overlay medium for viral plaque assays.
Matrosovich M, Matrosovich T, Garten W, Klenk HD. Matrosovich M, et al. Among authors: klenk hd. Virol J. 2006 Aug 31;3:63. doi: 10.1186/1743-422X-3-63. Virol J. 2006. PMID: 16945126 Free PMC article.
Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.
Böttcher-Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, Steinmetzer T, Klenk HD, Garten W. Böttcher-Friebertshäuser E, et al. Among authors: klenk hd. J Virol. 2010 Jun;84(11):5605-14. doi: 10.1128/JVI.00140-10. Epub 2010 Mar 17. J Virol. 2010. PMID: 20237084 Free PMC article.
Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.
Baron J, Tarnow C, Mayoli-Nüssle D, Schilling E, Meyer D, Hammami M, Schwalm F, Steinmetzer T, Guan Y, Garten W, Klenk HD, Böttcher-Friebertshäuser E. Baron J, et al. Among authors: klenk hd. J Virol. 2013 Feb;87(3):1811-20. doi: 10.1128/JVI.02320-12. Epub 2012 Nov 28. J Virol. 2013. PMID: 23192872 Free PMC article.
406 results