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Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.
Chem Sci. 2021 Nov 3;12(44):14758-14765. doi: 10.1039/d1sc04638a. eCollection 2021 Nov 17.
Chem Sci. 2021.
PMID: 34820091
Free PMC article.
FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.
Hähle A, Geiger TM, Merz S, Meyners C, Tianqi M, Kolos J, Hausch F.
Hähle A, et al.
PLoS One. 2019 Sep 6;14(9):e0221926. doi: 10.1371/journal.pone.0221926. eCollection 2019.
PLoS One. 2019.
PMID: 31490997
Free PMC article.
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Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity.
Voll AM, Meyners C, Taubert MC, Bajaj T, Heymann T, Merz S, Charalampidou A, Kolos J, Purder PL, Geiger TM, Wessig P, Gassen NC, Bracher A, Hausch F.
Voll AM, et al.
Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13257-13263. doi: 10.1002/anie.202017352. Epub 2021 May 7.
Angew Chem Int Ed Engl. 2021.
PMID: 33843131
Free PMC article.
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FKBP Ligands-Where We Are and Where to Go?
Kolos JM, Voll AM, Bauder M, Hausch F.
Kolos JM, et al.
Front Pharmacol. 2018 Dec 5;9:1425. doi: 10.3389/fphar.2018.01425. eCollection 2018.
Front Pharmacol. 2018.
PMID: 30568592
Free PMC article.
Review.
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Development of NanoBRET-Binding Assays for FKBP-Ligand Profiling in Living Cells.
Gnatzy MT, Geiger TM, Kuehn A, Gutfreund N, Walz M, Kolos JM, Hausch F.
Gnatzy MT, et al. Among authors: kolos jm.
Chembiochem. 2021 Jul 1;22(13):2257-2261. doi: 10.1002/cbic.202100113. Epub 2021 May 14.
Chembiochem. 2021.
PMID: 33887102
Free PMC article.
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[4.3.1]Bicyclic FKBP Ligands Inhibit Legionella Pneumophila Infection by LpMip-Dependent and LpMip-Independent Mechanisms.
Deutscher RCE, Safa Karagöz M, Purder PL, Kolos JM, Meyners C, Oki Sugiarto W, Krajczy P, Tebbe F, Geiger TM, Ünal C, Hellmich UA, Steinert M, Hausch F.
Deutscher RCE, et al. Among authors: kolos jm.
Chembiochem. 2023 Nov 2;24(21):e202300442. doi: 10.1002/cbic.202300442. Epub 2023 Sep 8.
Chembiochem. 2023.
PMID: 37489700
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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells.
Quist-Løkken I, Andersson-Rusch C, Kastnes MH, Kolos JM, Jatzlau J, Hella H, Olsen OE, Sundan A, Knaus P, Hausch F, Holien T.
Quist-Løkken I, et al. Among authors: kolos jm.
Cell Commun Signal. 2023 Jan 30;21(1):25. doi: 10.1186/s12964-022-01033-9.
Cell Commun Signal. 2023.
PMID: 36717825
Free PMC article.
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