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A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity.
Kostenis E, Martini L, Ellis J, Waldhoer M, Heydorn A, Rosenkilde MM, Norregaard PK, Jorgensen R, Whistler JL, Milligan G. Kostenis E, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):78-87. doi: 10.1124/jpet.104.080424. Epub 2004 Dec 22. J Pharmacol Exp Ther. 2005. PMID: 15615862
Heterotrimeric G-proteins: a short history.
Milligan G, Kostenis E. Milligan G, et al. Among authors: kostenis e. Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S46-55. doi: 10.1038/sj.bjp.0706405. Br J Pharmacol. 2006. PMID: 16402120 Free PMC article. Review.
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.
Schröder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, Müller A, Blättermann S, Mohr-Andrä M, Zahn S, Wenzel J, Smith NJ, Gomeza J, Drewke C, Milligan G, Mohr K, Kostenis E. Schröder R, et al. Among authors: kostenis e. Nat Biotechnol. 2010 Sep;28(9):943-9. doi: 10.1038/nbt.1671. Epub 2010 Aug 15. Nat Biotechnol. 2010. PMID: 20711173 Free article.
Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.
Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. Among authors: kostenis e. J Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23294321
196 results