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Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy.
Cosgrove D, Rodgers K, Meehan D, Miller C, Bovard K, Gilroy A, Gardner H, Kotelianski V, Gotwals P, Amatucci A, Kalluri R. Cosgrove D, et al. Among authors: kotelianski v. Am J Pathol. 2000 Nov;157(5):1649-59. doi: 10.1016/s0002-9440(10)64802-x. Am J Pathol. 2000. PMID: 11073824 Free PMC article.
Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates.
Petrov RA, Maklakova SY, Ivanenkov YA, Petrov SA, Sergeeva OV, Yamansarov EY, Saltykova IV, Kireev II, Alieva IB, Deyneka EV, Sofronova AA, Aladinskaia AV, Trofimenko AV, Yamidanov RS, Kovalev SV, Kotelianski VE, Zatsepin TS, Beloglazkina EK, Majouga AG. Petrov RA, et al. Among authors: kotelianski ve. Bioorg Med Chem Lett. 2018 Feb 1;28(3):382-387. doi: 10.1016/j.bmcl.2017.12.032. Epub 2017 Dec 14. Bioorg Med Chem Lett. 2018. PMID: 29269214
Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates.
Ivanenkov YA, Majouga AG, Petrov RA, Petrov SA, Kovalev SV, Maklakova SY, Yamansarov EY, Saltykova IV, Deyneka EV, Filkov GI, Kotelianski VE, Zatsepin TS, Beloglazkina EK. Ivanenkov YA, et al. Among authors: kotelianski ve. Bioorg Med Chem Lett. 2018 Feb 1;28(3):503-508. doi: 10.1016/j.bmcl.2017.12.004. Epub 2017 Dec 12. Bioorg Med Chem Lett. 2018. PMID: 29254645
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.
Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG. Dahlman JE, et al. Among authors: kotelianski v. Nat Nanotechnol. 2014 Aug;9(8):648-655. doi: 10.1038/nnano.2014.84. Epub 2014 May 11. Nat Nanotechnol. 2014. PMID: 24813696 Free PMC article.
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.
Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, Hutabarat RM, Clausen VA, Karsten V, Cehelsky J, Nochur SV, Kotelianski V, Horton J, Mant T, Chiesa J, Ritter J, Munisamy M, Vaishnaw AK, Gollob JA, Simon A. Fitzgerald K, et al. Among authors: kotelianski v. Lancet. 2014 Jan 4;383(9911):60-68. doi: 10.1016/S0140-6736(13)61914-5. Epub 2013 Oct 3. Lancet. 2014. PMID: 24094767 Free PMC article. Clinical Trial.
Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles.
Nakayama T, Butler JS, Sehgal A, Severgnini M, Racie T, Sharman J, Ding F, Morskaya SS, Brodsky J, Tchangov L, Kosovrasti V, Meys M, Nechev L, Wang G, Peng CG, Fang Y, Maier M, Rajeev KG, Li R, Hettinger J, Barros S, Clausen V, Zhang X, Wang Q, Hutabarat R, Dokholyan NV, Wolfrum C, Manoharan M, Kotelianski V, Stoffel M, Sah DW. Nakayama T, et al. Among authors: kotelianski v. Mol Ther. 2012 Aug;20(8):1582-9. doi: 10.1038/mt.2012.33. Epub 2012 Jun 5. Mol Ther. 2012. PMID: 22850721 Free PMC article.
14 results