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A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.
Nat Genet. 2014 Dec;46(12):1363-1371. doi: 10.1038/ng.3138. Epub 2014 Nov 2.
Nat Genet. 2014.
PMID: 25362484
Free PMC article.
Biophysical prediction of protein-peptide interactions and signaling networks using machine learning.
Cunningham JM, Koytiger G, Sorger PK, AlQuraishi M.
Cunningham JM, et al. Among authors: koytiger g.
Nat Methods. 2020 Feb;17(2):175-183. doi: 10.1038/s41592-019-0687-1. Epub 2020 Jan 6.
Nat Methods. 2020.
PMID: 31907444
Free PMC article.
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Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected.
Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G.
Koytiger G, et al.
Mol Cell Proteomics. 2013 May;12(5):1204-13. doi: 10.1074/mcp.M112.025858. Epub 2013 Jan 28.
Mol Cell Proteomics. 2013.
PMID: 23358503
Free PMC article.
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Crowdsourced mapping of unexplored target space of kinase inhibitors.
Cichońska A, Ravikumar B, Allaway RJ, Wan F, Park S, Isayev O, Li S, Mason M, Lamb A, Tanoli Z, Jeon M, Kim S, Popova M, Capuzzi S, Zeng J, Dang K, Koytiger G, Kang J, Wells CI, Willson TM; IDG-DREAM Drug-Kinase Binding Prediction Challenge Consortium; Oprea TI, Schlessinger A, Drewry DH, Stolovitzky G, Wennerberg K, Guinney J, Aittokallio T.
Cichońska A, et al. Among authors: koytiger g.
Nat Commun. 2021 Jun 3;12(1):3307. doi: 10.1038/s41467-021-23165-1.
Nat Commun. 2021.
PMID: 34083538
Free PMC article.
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Drug repurposing from the perspective of pharmaceutical companies.
Cha Y, Erez T, Reynolds IJ, Kumar D, Ross J, Koytiger G, Kusko R, Zeskind B, Risso S, Kagan E, Papapetropoulos S, Grossman I, Laifenfeld D.
Cha Y, et al. Among authors: koytiger g.
Br J Pharmacol. 2018 Jan;175(2):168-180. doi: 10.1111/bph.13798. Epub 2017 May 18.
Br J Pharmacol. 2018.
PMID: 28369768
Free PMC article.
Review.
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