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Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides.
Wolf-Levy H, Javitt A, Eisenberg-Lerner A, Kacen A, Ulman A, Sheban D, Dassa B, Fishbain-Yoskovitz V, Carmona-Rivera C, Kramer MP, Nudel N, Regev I, Zahavi L, Elinger D, Kaplan MJ, Morgenstern D, Levin Y, Merbl Y. Wolf-Levy H, et al. Among authors: kramer mp. Nat Biotechnol. 2018 Oct 22:10.1038/nbt.4279. doi: 10.1038/nbt.4279. Online ahead of print. Nat Biotechnol. 2018. PMID: 30346940 Free PMC article.
Golgi organization is regulated by proteasomal degradation.
Eisenberg-Lerner A, Benyair R, Hizkiahou N, Nudel N, Maor R, Kramer MP, Shmueli MD, Zigdon I, Cherniavsky Lev M, Ulman A, Sagiv JY, Dayan M, Dassa B, Rosenwald M, Shachar I, Li J, Wang Y, Dezorella N, Khan S, Porat Z, Shimoni E, Avinoam O, Merbl Y. Eisenberg-Lerner A, et al. Among authors: kramer mp. Nat Commun. 2020 Jan 21;11(1):409. doi: 10.1038/s41467-019-14038-9. Nat Commun. 2020. PMID: 31964869 Free PMC article.
Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors.
Kacen A, Javitt A, Kramer MP, Morgenstern D, Tsaban T, Shmueli MD, Teo GC, da Veiga Leprevost F, Barnea E, Yu F, Admon A, Eisenbach L, Samuels Y, Schueler-Furman O, Levin Y, Nesvizhskii AI, Merbl Y. Kacen A, et al. Among authors: kramer mp. Nat Biotechnol. 2023 Feb;41(2):239-251. doi: 10.1038/s41587-022-01464-2. Epub 2022 Oct 6. Nat Biotechnol. 2023. PMID: 36203013
The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC.
Javitt A, Shmueli MD, Kramer MP, Kolodziejczyk AA, Cohen IJ, Radomir L, Sheban D, Kamer I, Litchfield K, Bab-Dinitz E, Zadok O, Neiens V, Ulman A, Wolf-Levy H, Eisenberg-Lerner A, Kacen A, Alon M, Rêgo AT, Stacher-Priehse E, Lindner M, Koch I, Bar J, Swanton C, Samuels Y, Levin Y, da Fonseca PCA, Elinav E, Friedman N, Meiners S, Merbl Y. Javitt A, et al. Among authors: kramer mp. Nat Cancer. 2023 May;4(5):629-647. doi: 10.1038/s43018-023-00557-4. Epub 2023 May 22. Nat Cancer. 2023. PMID: 37217651
CD74 is a novel transcription regulator.
Gil-Yarom N, Radomir L, Sever L, Kramer MP, Lewinsky H, Bornstein C, Blecher-Gonen R, Barnett-Itzhaki Z, Mirkin V, Friedlander G, Shvidel L, Herishanu Y, Lolis EJ, Becker-Herman S, Amit I, Shachar I. Gil-Yarom N, et al. Among authors: kramer mp. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):562-567. doi: 10.1073/pnas.1612195114. Epub 2016 Dec 28. Proc Natl Acad Sci U S A. 2017. PMID: 28031488 Free PMC article.
CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia.
Lewinsky H, Barak AF, Huber V, Kramer MP, Radomir L, Sever L, Orr I, Mirkin V, Dezorella N, Shapiro M, Cohen Y, Shvidel L, Seiffert M, Herishanu Y, Becker-Herman S, Shachar I. Lewinsky H, et al. Among authors: kramer mp. J Clin Invest. 2018 Dec 3;128(12):5465-5478. doi: 10.1172/JCI96610. Epub 2018 Nov 5. J Clin Invest. 2018. PMID: 30277471 Free PMC article.
50 results