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A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress.
Fedeles BI, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade DC, Westergerling P, Staudner T, Campolo J, Liu SS, Dong K, Cai Y, Rehman M, Gallagher AR, Ruchirawat S, Croy RG, Essigmann JM, Fedeles SV, Somlo S. Fedeles BI, et al. Among authors: krappitz m. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2317344121. doi: 10.1073/pnas.2317344121. Epub 2024 Jan 19. Proc Natl Acad Sci U S A. 2024. PMID: 38241440 Free PMC article.
Is it Time to Fold the Cysts Away?
Krappitz M, Gallagher AR, Fedeles S. Krappitz M, et al. Trends Mol Med. 2016 Dec;22(12):997-999. doi: 10.1016/j.molmed.2016.10.001. Epub 2016 Oct 25. Trends Mol Med. 2016. PMID: 27793600
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.
Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW. Lieu T, et al. Among authors: krappitz m. Gastroenterology. 2014 Dec;147(6):1417-28. doi: 10.1053/j.gastro.2014.08.042. Epub 2014 Sep 3. Gastroenterology. 2014. PMID: 25194674 Free PMC article.
12 results