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Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.
Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Zhang Q, et al. Among authors: rose kl. Nat Cell Biol. 2021 Dec;23(12):1240-1254. doi: 10.1038/s41556-021-00805-8. Epub 2021 Dec 9. Nat Cell Biol. 2021. PMID: 34887515 Free PMC article.
CHK1 phosphorylates PRIMPOL to promote replication stress tolerance.
Mehta KPM, Thada V, Zhao R, Krishnamoorthy A, Leser M, Lindsey Rose K, Cortez D. Mehta KPM, et al. Among authors: lindsey rose k. Sci Adv. 2022 Apr;8(13):eabm0314. doi: 10.1126/sciadv.abm0314. Epub 2022 Mar 30. Sci Adv. 2022. PMID: 35353580 Free PMC article.
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik SW, Liu Q, Tansey WP. Howard GC, et al. Among authors: rose kl. bioRxiv [Preprint]. 2024 Jan 10:2023.07.26.550648. doi: 10.1101/2023.07.26.550648. bioRxiv. 2024. PMID: 37546802 Free PMC article. Preprint.
SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.
Vassilopoulos A, Pennington JD, Andresson T, Rees DM, Bosley AD, Fearnley IM, Ham A, Flynn CR, Hill S, Rose KL, Kim HS, Deng CX, Walker JE, Gius D. Vassilopoulos A, et al. Among authors: rose kl. Antioxid Redox Signal. 2014 Aug 1;21(4):551-64. doi: 10.1089/ars.2013.5420. Epub 2014 Mar 6. Antioxid Redox Signal. 2014. PMID: 24252090 Free PMC article.
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