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Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation.
Zhou E, Ge X, Nakashima H, Li R, van der Zande HJP, Liu C, Li Z, Müller C, Bracher F, Mohammed Y, de Boer JF, Kuipers F, Guigas B, Glass CK, Rensen PCN, Giera M, Wang Y. Zhou E, et al. Among authors: kuipers f. EMBO Mol Med. 2023 Aug 7;15(8):e16845. doi: 10.15252/emmm.202216845. Epub 2023 Jun 26. EMBO Mol Med. 2023. PMID: 37357756 Free PMC article.
Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice.
Heida A, van Dijk T, Smit M, Koehorst M, Koster M, Kloosterhuis N, Havinga R, Bloks VW, Wolters JC, de Bruin A, Kuivenhoven JA, de Boer JF, Kuipers F, van de Sluis B. Heida A, et al. Among authors: kuipers f. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Mar;1869(2):159445. doi: 10.1016/j.bbalip.2023.159445. Epub 2023 Dec 11. Biochim Biophys Acta Mol Cell Biol Lipids. 2024. PMID: 38086439 Free article.
Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition.
Sjöland W, Wahlström A, Makki K, Schöler M, Molinaro A, Olsson L, Greiner TU, Caesar R, de Boer JF, Kuipers F, Bäckhed F, Marschall HU. Sjöland W, et al. Among authors: kuipers f. Clin Sci (Lond). 2023 Jul 14;137(13):995-1011. doi: 10.1042/CS20230413. Clin Sci (Lond). 2023. PMID: 37384590 Free PMC article.
Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis.
Dehondt H, Marino A, Butruille L, Mogilenko DA, Nzoussi Loubota AC, Chávez-Talavera O, Dorchies E, Vallez E, Haas J, Derudas B, Bongiovanni A, Tardivel M, Kuipers F, Lefebvre P, Lestavel S, Tailleux A, Dombrowicz D, Caron S, Staels B. Dehondt H, et al. Among authors: kuipers f. Mol Metab. 2023 Mar;69:101686. doi: 10.1016/j.molmet.2023.101686. Epub 2023 Feb 4. Mol Metab. 2023. PMID: 36746333 Free PMC article.
Role of bile acid receptor FXR in development and function of brown adipose tissue.
Yang J, de Vries HD, Mayeuf-Louchart A, Stroeve JH, Bloks VW, Koehorst M, Duez H, Staels B, Kuipers F, van Zutphen T. Yang J, et al. Among authors: kuipers f. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Feb;1868(2):159257. doi: 10.1016/j.bbalip.2022.159257. Epub 2022 Nov 17. Biochim Biophys Acta Mol Cell Biol Lipids. 2023. PMID: 36402299 Free article.
483 results