Kwiatkowski DJ - Search Results

1

Response and acquired resistance to everolimus in anaplastic thyroid cancer.

Wagle N, Grabiner BC, Van Allen EM, Amin-Mansour A, Taylor-Weiner A, Rosenberg M, Gray N, Barletta JA, Guo Y, Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G, Kwiatkowski DJ, Carter SL, Sabatini DM, Jänne PA, Garraway LA, Lorch JH. Wagle N, et al. Among authors: kwiatkowski dj. N Engl J Med. 2014 Oct 9;371(15):1426-33. doi: 10.1056/NEJMoa1403352. N Engl J Med. 2014. PMID: 25295501 Free PMC article.

2

Mosaicism in tuberous sclerosis as a potential cause of the failure of molecular diagnosis.

Kwiatkowska J, Wigowska-Sowinska J, Napierala D, Slomski R, Kwiatkowski DJ. Kwiatkowska J, et al. Among authors: kwiatkowski dj. N Engl J Med. 1999 Mar 4;340(9):703-7. doi: 10.1056/NEJM199903043400905. N Engl J Med. 1999. PMID: 10053179 Free article. No abstract available.

3

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tee AR, et al. Among authors: kwiatkowski dj. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. doi: 10.1073/pnas.202476899. Epub 2002 Sep 23. Proc Natl Acad Sci U S A. 2002. PMID: 12271141 Free PMC article.

4

LKB1 modulates lung cancer differentiation and metastasis.

Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. Ji H, et al. Among authors: kwiatkowski dj. Nature. 2007 Aug 16;448(7155):807-10. doi: 10.1038/nature06030. Epub 2007 Aug 5. Nature. 2007. PMID: 17676035

5

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.

Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ. Meikle L, et al. Among authors: kwiatkowski dj. J Neurosci. 2008 May 21;28(21):5422-32. doi: 10.1523/JNEUROSCI.0955-08.2008. J Neurosci. 2008. PMID: 18495876 Free PMC article.

6

Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors.

Wagner AJ, Malinowska-Kolodziej I, Morgan JA, Qin W, Fletcher CD, Vena N, Ligon AH, Antonescu CR, Ramaiya NH, Demetri GD, Kwiatkowski DJ, Maki RG. Wagner AJ, et al. Among authors: kwiatkowski dj. J Clin Oncol. 2010 Feb 10;28(5):835-40. doi: 10.1200/JCO.2009.25.2981. Epub 2010 Jan 4. J Clin Oncol. 2010. PMID: 20048174 Free PMC article.

7

Ultra deep sequencing detects a low rate of mosaic mutations in tuberous sclerosis complex.

Qin W, Kozlowski P, Taillon BE, Bouffard P, Holmes AJ, Janne P, Camposano S, Thiele E, Franz D, Kwiatkowski DJ. Qin W, et al. Among authors: kwiatkowski dj. Hum Genet. 2010 Mar;127(5):573-82. doi: 10.1007/s00439-010-0801-z. Epub 2010 Feb 18. Hum Genet. 2010. PMID: 20165957 Free PMC article.

8

The introduction of systematic genomic testing for patients with non-small-cell lung cancer.

Cardarella S, Ortiz TM, Joshi VA, Butaney M, Jackman DM, Kwiatkowski DJ, Yeap BY, Jänne PA, Lindeman NI, Johnson BE. Cardarella S, et al. Among authors: kwiatkowski dj. J Thorac Oncol. 2012 Dec;7(12):1767-1774. doi: 10.1097/JTO.0b013e3182745bcb. J Thorac Oncol. 2012. PMID: 23154547 Free PMC article.

9

Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis.

Guo Y, Kwiatkowski DJ. Guo Y, et al. Among authors: kwiatkowski dj. Mol Cancer Res. 2013 May;11(5):467-73. doi: 10.1158/1541-7786.MCR-12-0605. Epub 2013 Feb 5. Mol Cancer Res. 2013. PMID: 23386687 Free PMC article.

10

TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.

Guo Y, Chekaluk Y, Zhang J, Du J, Gray NS, Wu CL, Kwiatkowski DJ. Guo Y, et al. Among authors: kwiatkowski dj. J Pathol. 2013 May;230(1):17-27. doi: 10.1002/path.4176. Epub 2013 Mar 21. J Pathol. 2013. PMID: 23401075

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