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Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties.
McCubrey JA, Meher AK, Akula SM, Abrams SL, Steelman LS, LaHair MM, Franklin RA, Martelli AM, Ratti S, Cocco L, Barbaro F, Duda P, Gizak A. McCubrey JA, et al. Among authors: lahair mm. Aging (Albany NY). 2022 Apr 27;14(8):3365-3386. doi: 10.18632/aging.204038. Epub 2022 Apr 27. Aging (Albany NY). 2022. PMID: 35477123 Free PMC article.
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
Chappell WH, Abrams SL, Franklin RA, LaHair MM, Montalto G, Cervello M, Martelli AM, Nicoletti F, Candido S, Libra M, Polesel J, Talamini R, Milella M, Tafuri A, Steelman LS, McCubrey JA. Chappell WH, et al. Among authors: lahair mm. Cell Cycle. 2012 Dec 1;11(23):4447-61. doi: 10.4161/cc.22786. Epub 2012 Nov 16. Cell Cycle. 2012. PMID: 23159854 Free PMC article.
OSU-03012 in the treatment of glioblastoma.
McCubrey JA, Lahair MM, Franklin RA. McCubrey JA, et al. Among authors: lahair mm. Mol Pharmacol. 2006 Aug;70(2):437-9. doi: 10.1124/mol.106.026252. Epub 2006 May 4. Mol Pharmacol. 2006. PMID: 16675657
Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.
Chappell WH, Abrams SL, Stadelman KM, LaHair MM, Franklin RA, Cocco L, Evangelisti C, Chiarini F, Martelli AM, Steelman LS, McCubrey JA. Chappell WH, et al. Among authors: lahair mm. Adv Biol Regul. 2013 Jan;53(1):146-55. doi: 10.1016/j.jbior.2012.09.004. Epub 2012 Sep 16. Adv Biol Regul. 2013. PMID: 23073564 No abstract available.
15 results