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Page 1
Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin.
Hill J, Siedlecki J, Parr I, Morytko M, Yu X, Zhang Y, Silverman J, Controneo N, Laganas V, Li T, Lai JJ, Keith D, Shimer G, Finn J. Hill J, et al. Among authors: laganas v. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4187-91. doi: 10.1016/j.bmcl.2003.07.019. Bioorg Med Chem Lett. 2003. PMID: 14622998
Array synthesis of novel lipodepsipeptide.
Siedlecki J, Hill J, Parr I, Yu X, Morytko M, Zhang Y, Silverman J, Controneo N, Laganas V, Li T, Li J, Keith D, Shimer G, Finn J. Siedlecki J, et al. Among authors: laganas v. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4245-9. doi: 10.1016/j.bmcl.2003.07.025. Bioorg Med Chem Lett. 2003. PMID: 14623010
Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
Murphy-Benenato KE, Gingipalli L, Boriack-Sjodin PA, Martinez-Botella G, Carcanague D, Eyermann CJ, Gowravaram M, Harang J, Hale MR, Ioannidis G, Jahic H, Johnstone M, Kutschke A, Laganas VA, Loch JT 3rd, Miller MD, Oguto H, Patel SJ. Murphy-Benenato KE, et al. Among authors: laganas va. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5172-7. doi: 10.1016/j.bmcl.2015.09.075. Epub 2015 Oct 14. Bioorg Med Chem Lett. 2015. PMID: 26463129
Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. de Jonge BL, et al. Among authors: laganas v. Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. Epub 2013 Sep 16. Antimicrob Agents Chemother. 2013. PMID: 24041904 Free PMC article.