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A hydrophobic ratchet entrenches molecular complexes.
Hochberg GKA, Liu Y, Marklund EG, Metzger BPH, Laganowsky A, Thornton JW. Hochberg GKA, et al. Among authors: laganowsky a. Nature. 2020 Dec;588(7838):503-508. doi: 10.1038/s41586-020-3021-2. Epub 2020 Dec 9. Nature. 2020. PMID: 33299178 Free PMC article.
C-terminal interactions mediate the quaternary dynamics of αB-crystallin.
Hilton GR, Hochberg GK, Laganowsky A, McGinnigle SI, Baldwin AJ, Benesch JL. Hilton GR, et al. Among authors: laganowsky a. Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110405. doi: 10.1098/rstb.2011.0405. Print 2013 May 5. Philos Trans R Soc Lond B Biol Sci. 2013. PMID: 23530258 Free PMC article.
The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity.
Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. Hochberg GK, et al. Among authors: laganowsky a. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1562-70. doi: 10.1073/pnas.1322673111. Epub 2014 Apr 7. Proc Natl Acad Sci U S A. 2014. PMID: 24711386 Free PMC article.
96 results