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Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.
Granfors MT, Backman JT, Laitila J, Neuvonen PJ. Granfors MT, et al. Among authors: laitila j. Br J Clin Pharmacol. 2004 Mar;57(3):349-53. doi: 10.1046/j.1365-2125.2003.02028.x. Br J Clin Pharmacol. 2004. PMID: 14998432 Free PMC article.
Cyclosporine markedly raises the plasma concentrations of repaglinide.
Kajosaari LI, Niemi M, Neuvonen M, Laitila J, Neuvonen PJ, Backman JT. Kajosaari LI, et al. Among authors: laitila j. Clin Pharmacol Ther. 2005 Oct;78(4):388-99. doi: 10.1016/j.clpt.2005.07.005. Clin Pharmacol Ther. 2005. PMID: 16198658 Clinical Trial.
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