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A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice.
Wake M, Palin A, Belot A, Berger M, Lorgouilloux M, Bichon M, Papworth J, Bayliss L, Grimshaw B, Rynkiewicz N, Paterson J, Poindron A, Spearing E, Carter E, Hudson R, Campbell M, Petzer V, Besson-Fournier C, Latour C, Largounez A, Gourbeyre O, Fay A, Coppin H, Roth MP, Theurl I, Germaschewski V, Meynard D. Wake M, et al. Among authors: largounez a. Blood Adv. 2024 Apr 23;8(8):1898-1907. doi: 10.1182/bloodadvances.2023012010. Blood Adv. 2024. PMID: 38241484 Free PMC article.
Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR.
Belot A, Gourbeyre O, Palin A, Rubio A, Largounez A, Besson-Fournier C, Latour C, Lorgouilloux M, Gallitz I, Montagner A, Polizzi A, Régnier M, Smati S, Zhang AS, Diaz-Munoz MD, Steinbicker AU, Guillou H, Roth MP, Coppin H, Meynard D. Belot A, et al. Among authors: largounez a. Haematologica. 2021 Apr 1;106(4):1202-1206. doi: 10.3324/haematol.2019.237321. Haematologica. 2021. PMID: 32703788 Free PMC article. No abstract available.